Stochastic Modeling on Drug Efficacy in Self Drug Administration Health Problems

P. Tirupathi Rao, M. Venkateswaran, R. Vishnu Vardhan
DOI: 10.4236/jssm.2011.44056                

Abstract

Evaluation of drug impact both on positive and negative sides is very important to monitor the drug administration during the treatment. The effectiveness of drug is a variable due to various chance and assignable causes. Evaluation of drug efficacy through conventional mathematical modeling is the existing practice. In this paper we proposed a Stochastic model for measuring the drug efficacy for Non-Clinical and short term drug administration practices. Sensitivity analysis is carried out to observe the model behavior. Development of computer software and desktop templates to this model will provide effective decision support systems for health caretakers.

Keywords

Stochastic Modeling, Drug efficacy; Self drug administration

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	S. H. Daukes, “A Consideration of the Various Methods of Drug Administration,” Post Graduate Medical Journal, Vol. 5, No. 49, 1929, pp. 1-7. doi:10.1136/pgmj.5.49.1
[2]	J. Smieja, et al., “Optimal Control for the Model of Drug Resistance Resulting from Gen Amplification,” Preperation of the 14th IFAC World Congress, Beijing, China, Vol. 50, 1999, pp. 71-75.
[3]	A. Swierniak et al., “Asymptotic Properties of Infinite Dimensional Model Drug Resistance Evolution,” Proceedings of the European Control Conference (ECC), Brussels, 1997.
[4]	W. E. Evans and H. L. McLeod, “Pharmacogenomics— drug disposition, drug targets, and side effects,” New England Journal of Medicine, Vol. 348, No. 6, 2003, pp. 538-549. doi:10.1056/NEJMra020526
[5]	C. Abad-Zapatero and J. T. Metz, “Ligand Efficiency In- dices as Guideposts for Drug Discovery,” Drug Discovery Today, Vol. 10, No. 7, 2005, pp. 464-469. doi:10.1016/S1359-6446(05)03386-6
[6]	C. Hetenyi, et al., “Structure-Based Calculation of Drug Efficiency Indices,” Journal of Structural Bioinformatics, Vol. 23, No. 20, 2007, pp. 2678-2685. doi:10.1093/bioinformatics/btm431
[7]	P. Tirupathi Rao and R. Bharathi, “Stochastic Modeling in the Evaluation of Drug Efficiency,” International Journal of Statistics and System, Vol. 5, No. 3, 2010, pp. 427-438.