Evaluation of Toxicity of Phenolic Compounds Using Aedes aegypti (Diptera: Culicidae) and Artemia salina


Nowadays, dengue fever, a mosquito-borne tropical disease, has become widely distributed in Brazil. In order to prevent such disease, the population of Aedes aegypti mosquito has to be controlled. Then, the aim of this study is to assess the toxicological effects of phenolic compounds against dengue mosquitos. Hence, the larvicidal activity and toxicity of phenolic compounds against Ae. aegypti larvae and A. salina, are evaluated, respectively. The phenolic compounds 2,6-diiodophenol and 4-chloro-2,6-diiodophenol have different toxicity and larvicidal activity. The compound 4-chloro-2,6-diiodophenol shows the highest toxicity for larvae of Ae. aegypti, exhibiting higher toxicity than 2,6-diiodophenol. Although less toxic than Temephos®(organophosphate), the phenolic compounds evaluated by this research, are proved to be effective against Ae. aegypti larvae. This study demonstrates the importance of controlling the dengue mosquito, considering toxicological aspects of phenolic compounds to prevent environmental impacts.

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Catelan, T. , Arruda, E. , Oliveira, L. , Raminelli, C. , Gaban, C. , Cabrini, I. , Nova, P. and Carbonaro, E. (2015) Evaluation of Toxicity of Phenolic Compounds Using Aedes aegypti (Diptera: Culicidae) and Artemia salina. Advances in Infectious Diseases, 5, 48-56. doi: 10.4236/aid.2015.51005.

Conflicts of Interest

The authors declare no conflicts of interest.


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