Comparative Study between the Effect of Momordica charantia (Wild Type) Fruits and Coccinia cordifolia’s Leaf on Hypoglycemic and Hypolipidemic Activities of Alloxan

Dipa Islam, Evena Parvin Lipy, Samiur Rahman, Liton Chandra Mohanta, Khaledun Nahar Babi

Animal Research Section, Institute of Food Science and Technology, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.
BCSIR Laboratories Dhaka, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.

DOI: 10.4236/jdm.2014.42018                

Abstract

Aims: The study was aimed to compare the hypoglycemic and hypolipidemic effect of Momordica charantia (wild type) fruits and Coccinia cordifolia’s leaf in alloxan induced type 2 diabetic Long-Evans rats. Methods: All rats were divided into groups A to H (n = 48, 06 rats per group). They were made diabetic by intraperitoneally injecting alloxan monohydrate 150-mg/Kg-body weight. Groups A and B were provided with normal diet and glibenclamide plus normal diet respectively. C to H groups were provided with different percentages (70%, 50% and 30% of regular diet) of samples. Different biochemical parameters (blood glucose level, serum total cholesterol, triglyceride (TG), LDL, HDL, serum insulin, hepatic glycogen) were observed for 21 consecutive days (at eight days interval). Results: Oral administration of both of the Momordica charantia (wild type) fruits and Coccinia cordifolia’s leaf significantly (p < 0.05) improved hypoglycemic status by decreasing fasting blood glucose level. Hypolipidemic status also observed, and found improved significantly (p < 0.05) by decreasing the level of serum total cholesterol, triglyceride (TG), serum insulin level and LDL in type 2 diabetic rats. HDL levels were increased slightly and hepatic glycogen level was more or less unchanged in both groups at 22nd day. Conclusion: Though both samples show hypoglycemic and hypolipidemic activities, 50% wild type fruits of Momordica charantia were more significant (p < 0.05) to ameliorate the diabetic state in type 2 diabetic Long-Evans rats.

Keywords

Diabetics, Alloxan Monohydrate, Hypoglycemia, Hypolipidemia

Conflicts of Interest

The authors declare no conflicts of interest.

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