Oxone-Mediated Oxidative Esterification of Heterocyclic Aldehydes Using Indium(III) Triflate

Tomoko Mineno, Saki Yoshino, Akira Ubukata

aboratory of Medicinal Chemistry, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Japan.
Laboratory of Medicinal Chemistry, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Japan.

DOI: 10.4236/gsc.2014.41004                

Abstract

Recent investigations have shown the oxone-mediated oxidative methyl esterification of benzaldehyde derivatives using methanol. The reactions were accelerated in the presence of indium(III) triflate, a trivalent indium reagent, in many cases. Based on this method of methyl esterification of benzaldehyde derivatives, we further explored an application to heterocyclic aldehydes. The reactions were examined using methanol as well as other alcohols in order to establish a suitable range.

Keywords

Oxidative Esterification; Heterocyclic Aldehydes; Indium(III) Triflate

Conflicts of Interest

The authors declare no conflicts of interest.

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