Endovascular Repair of an Infected Broken Pseudoaneurysm of the Extracranial Internal Carotid Artery

Claude Michel, Alain Parot, Patrick Jue Denis, Pierre-Yves Laffy, Jean-Yves Riou, Gilbert Leblanc

Cardio-Vascular Radiology Department, Marie Lannelongue Hospital, Le Plessis Robinson, France.
Vascular Radiology Department, Europe Medico-Surgical Center, Le Port Marly, France.
Vascular Surgery Department, Europe Medico-Surgical Center, Le Port Marly, France.

DOI: 10.4236/ojrad.2012.24020                

Abstract

The formation of pseudoaneurysms after carotid endarterectomy is extremely rare. Treating those pseudoaneuryms is necessary because of the risks for continued expansion, rupture and distal embolism. Traditional surgical repair of carotid artery pseudoaneurysms is associated with a high morbidity and mortality. An endovascular approach to these infected pseudoaneurysms limits the risk for operative damage to surrounding structures and potential blood loss.

Keywords

Carotid Artery; Pseudoaneurysm; Covered Self Expandable Stent

1. Introduction

The pseudoaneurysm of the internal carotid artery in its extracranial segment is among the rare diagnoses [1,2] that must systematically be envisaged when faced with a pulsating mass in the cervical area or more rarely in the tonsil area [3]. The variability of the symptomatology makes this diagnosis difficult. Traditionally, the treatment is of a surgical nature [4,5]. In this paper, we report a case of infected pseudoaneurysm of the internal carotid artery apparently looking like an abscess on the lateral part of the pharynx. Based on existing reports and on this particular case, this paper describes the approach to this pathology.

2. Case Report

A 72-year-old patient arriving from Kinshasa was admitted in the nephrology department because of a kidney insufficiency. He had a past medical history of arterial hypertension, diabetes with an insulin dependence, a type C hepatitis and an endarterectomy of the left internal carotid artery with a widening Dacron patch.

When admitted in the department, he had a temperature of 40˚C and a dysphagia, and a left laterocervical mass with a fistula located in the mid-segment of the scar of the endarterectomy. The physical neurologic examination was normal and there was no anomaly of the cranial nerves. The kidney insufficiency was significant with a blood area level of 1.96 gram/L. Creatinemia was 101 mg/L, the alkaline reserve was 16 mmol/L, an inflamematory syndrome with a VS of 94 mm/L during the first hour and a CRP of 12 mg/L. A dialysis catheter was installed in the right jugular vein while an antibiotic therapy was administered, using Vancomycine and Gentalline followed by Tienam Gentalline, given the presence of a Beta Lactonase with a wide spectrum (BLSE) in the sample of pus coming from the fistula. An infection of his endarterectomy Dacron patch was suspected. The left cervical ultrasound showed an irregular shaped mass adjacent to the internal carotid artery while the Power Doppler Ultrasound showed an ectasia with a blood flow in it. All this was compatible with a pseudoaneurysm. The damage was adjacent to the fistula. The thoracic cervical computed tomography showed that the left laterocervical mass was partly necrosed with a skin fistula including the carotid artery bifurcation and the sternocleidomastoid muscle with, within the mass, the partly thrombosed pseudoaneurysm of the internal carotid artery compressing the internal jugular vein (Figure 1). The arteriography of the supra-aortic trunks also showed the pseudoaneurysm of the internal carotid artery in its extracranial segment (Figure 2), a normal Willis polygon and no distal embolism in the left brain hemisphere. Following discussions within the medical staff, the decision was made to treat the pseudoaneurysm by an endovascular approach and the use of antibiotics. This was to be followed by a surgical debridement of the infected tissue and the excision of the Dacron patch.

Figure 1. Preoperative computed tomography angiogram: Pseudo aneurysm of left internal carotid artery with surrounding infected tissues.

Figure 2. Selective angiography of the left internal carotid artery : Pseudoaneurysm at the bulb base.

The patient was premedicated with Clopidogrel 75 mg/24 hr and aspirin 100 mg three days before the procedure (20/09/2011) which was to be conducted under local anesthesia. An 8F guiding catheter (Boston Scientific) was advanced in the left common carotid artery through a right femoral artery approach. A 5000 Heparine units intraveinous bolus followed by a 1000 units/ hour perfusion was administered to keep the ACT ≥ 200. A stiff AMPLATZ (Boston Scientific) guidewire was pushed beyond the aneurysmal neck until its end reached the mid-part of the left internal carotid artery. Subsequently, a 6 × 36 mm PTFE covered graft stent Fluency (BARD) was advanced and deployed over the guidewire through the neck of the pseudoaneurysm. The angiographic control showed that the left carotid artery was leaking. The decision was then made to install another 7 × 37 mm covered stent (FLUENCY) impacting in the mid-section of the first stent and opening out in the common carotid artery. The final angiographic control showed that the neck was closed without any opacification of the sac and also showed the occlusion of the external carotid artery (Figure 3). Beyond the aneurysm, the distal brain vascularization remained normal.

The patient was then transferred to the vascular surgical unit to excise the left cervical abscess. Following the pre-sternocleidomastoidal incision in the collection of pus, the pseudoaneurysm was found again in the form of a clot with a free PTFE patch, a part of the internal saphenous vein was taken and sutured on the previous arteriotomy so that the endoprotheses were covered and isolated from the infected lesions. The patient was then transferred to the intensive care unit to continue the antibiotic treatment with Tienam, Aspegic 250 mg/day and a subcutaneous injection of Calciparine 0.3 three times a day. A few days later, he was discharged home from the Europe Medico Surgical Center and treated with Aspegic 100 mg/day, Plavix 60 mg/day for 6 months and Teradiene for 6 weeks. After 2 months, an ambulatory control was performed, consisting in a computed tomography

Figure 3. Angiogram of the left common carotid artery following deployment of self expandable covered stents fluency (Bard): Total exclusion of the pseudoaneurysm is observed.

angiogram. It demonstrated the stability of the occlusion and the pseudoaneurysm without any evidence of stenosis (Figure 4). The patient was asymptomatic and had no neurological problem.

3. Discussion

Pseudoaneurysm formation is reported to occur after fewer than 1% of all CEAs [6]. The underlying factors that may lead to post-CEA pseudoaneurysm formation include suture line failure, deterioration of the patch or of the artery wall and infection [7]. Spontaneous evolutions are an increase in size, the appearance of thrombosis, an extrinsic compression, embolism causing cerebral ischemic events in more than 50% of the cases and a rupture generating a massive hemorrhage in 50% to 70% of the cases. The volume increase may cause dysphagia, neurological events on one side with a Claude Bernard Horner syndrome, paralysis of the cranial nerves (IX, X and XII) [8]. The traditional surgical treatment consists in an aneurysmectomy and a debridement of the infected tissues, excision of the patch which is replaced by a veinous or prothetic graft [9]. This procedure is complex [10,11] because it means operating in infected areas modified by previous surgery. In addition, in function of the part of the carotid artery concerned and the size of the pseudoaneurysm, a proximal control of the carotid artery may demand a clavicular resection while the distal access may require a mandibular dislocation. The complete proximal and distal ligature of the carotid artery was recommended in the case of giant aneurysms with hemorrhages in order to save the patient’s life [12]. The rate

Figure 4. CTscan at 6 months follow-up showing persistant exclusion of the pseudoaneurysm and no stenosis of covered stents.

of mortality and major neurological events is 10%. Consequently, less aggressive endovascular techniques were recommended to avoid surgical complications. The selective embolisation procedure of the aneurysmal sac and the installation of metallic coils through the meshes of a stent was successfully achieved and preserved the permeability of the internal carotid artery while achieving a selective thrombosis of the aneurysmal sac [13]. This procedure presents a risk of rupture of the aneurysmal sac during the manipulation of the micro-catheter or of an incomplete occlusion of the pseudoaneurysm and the migration of thrombogenic material in the internal carotid artery. The percutaneous injection of Thrombine is contra-indicated in the case of infected pseudoaneurysms [14,15]. The endovascular use of endografts is attractive thanks to their capacity to isolate the aneurysm immediately while maintaining the carotid flow without resorting to general anesthesia [16-18]. However, the use of an endograft to treat pseudoaneurysms after an endarterectomy may be risky [19]. The possibility of an embolisation while passing the guidewire and during the installation of of the material must be taken into account [20], the more so as it turned out to be impossible to install an endoprothesis on a protective guide. In the present case, there was no filtering guidewire and the patient had no neurological events. A thrombosis of the endoprothesis may occur even if the patient is under anti-platelet therapy [21]. The patency of the external carotid was not the subject in account the risk of rupture. A possibility of restenosis always remains, particularly at the ends of the endoprothesis [22]. The long term durability of this kind of endovascular treatment still has to be determined [23]. An infection of the endoprothesis is always possible and demands repeated controls. A recurrent infection may justify—under antibiotherapy—an aneurysmectomy including the excision of the endoprothesis, the debridement of the infected tissues and an autogenous graft replacement and a carotid artery ligation with or without extra-anatomic bypass [24].

4. Conclusion

The standard treatment of infected aneurysms of the internal carotid artery is still the traditional open repair, consisting in an aneurysmectomy, debridement of the surrounding infected tissues and autogenous graft replacement, ligation of the carotid artery or extraanatomic bypass. However, in this particular case, the result indicates that the installation of a covered endoprothesis may be an effective option for the treatment of carotid artery pseudoaneurysms in the case of selected high risk patients to limit the risks for rupture, massive hemorrhage or embolisation.

Conflicts of Interest

The authors declare no conflicts of interest.

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