[1]
|
Xavier, R.J. and Podolsky, D.K. (2007) Unravelling the pathogenesis of inflammatory bowel disease. Nature, 448,427-434. doi:10.1038/nature06005
|
[2]
|
Brown, S.J. and Mayer, L. (2007) The immune response in inflammatory bowel disease. The American Journal of Gastroenterology, 102, 2058-2069. doi:10.1111/j.1572-0241.2007.01343.x
|
[3]
|
Mudter, J. (2011) What’s new about inflammatory bowel diseases in 2011. World Journal of Gastroenterology, 17, 3177.
|
[4]
|
Liu, Z., Yadav, P.K., Su, J.L., et al. (2009) Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease. World Journal of Gastroenterology, 15, 5784-5788. doi:10.3748/wjg.15.5784
|
[5]
|
Peyrin-Biroulet, L., Vignal, C., Dessein, R., et al. (2009) NODs in defence: From vulnerable antimicrobial peptides to chronic inflammation. Trends in Microbiology, 14, 432-438. doi:10.1016/j.tim.2006.08.008
|
[6]
|
Peters, B.M., Shirtliff, M.E. and Jabra-Rizk, M.A. (2010) Antimicrobial peptides: Primeval molecules or future drugs? Public Library of Science Pathogens, 6, 1001067. doi:10.1371/journal.ppat.1001067
|
[7]
|
Steinstraesser, L., Kraneburg, U., Jacobsen, F. and Al-Benna, S. (2011) Host defense peptides and their antimicrobial-immunomodulatory duality. Immunobiology, 216, 322-333. doi:10.1016/j.imbio.2010.07.003
|
[8]
|
Hazlett, L. and Wu, M. (2011) Defensins in innate immunity. Cell and Tissue Research, 343, 175-188. doi:10.1007/s00441-010-1022-4
|
[9]
|
Arijs, I., De, Hertogh, G., Lemaire, K., et al. (2009) Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment. Public Library of Science Pathogens One, 4, 79-84. doi:10.1371/journal.pone.0007984
|
[10]
|
Zasloff, M. (2002) Antimicrobial peptides of multicellular organisms. Nature, 415, 389-395. doi:10.1038/415389a
|
[11]
|
Szyk, A., Wu, Z., Tucker, K., et al. (2006) Crystal structures of human alpha-defensins HNP4, HD5, and HD6. Protein Science, 15, 2749-2760. doi:10.1110/ps.062336606
|
[12]
|
Duclohier, H. (2010) Antimicrobial peptides and peptaibols, substitutes for conventional antibiotics. Current Pharmaceutical, 16, 3212-3223. doi:10.2174/138161210793292500
|
[13]
|
Tecle, T., Tripathi, S. and Hartshorn, K.L. (2010) Review: Defensins and cathelicidins in lung immunity. Innate Immunity, 16, 151-159. doi:10.1177/1753425910365734
|
[14]
|
Underwood, M.A. and Bevins, C.L. (2010) Defensin-barbed innate immunity: Clinical associations in the pediatric population. Pediatrics, 125, 1237-1247. doi:10.1542/peds.2009-3289
|
[15]
|
Zilbauer, M., Jenke, A., Wenzel, G., et al. (2011) Intestinal alpha-defensin expression in pediatric inflammatory bowel disease. Inflammatory Bowel Disease, 17, 2076-2086. doi:10.1002/ibd.21577
|
[16]
|
Ferguson, L.R., Browning, B.L., Huebner, C., et al. (2008) Single nucleotide polymorphisms in human Paneth cell defensin A5 may confer susceptibility to inflammatory bowel disease in a New Zealand Caucasian population. Digestive and Liver Disease, 40, 723-730. doi:10.1016/j.dld.2008.02.011
|
[17]
|
Shi, J. (2007) Defensins and Paneth cells in inflammatory bowel disease. Inflammatory Bowel Diseases, 13, 1284-1292. doi:10.1002/ibd.20197
|
[18]
|
Ramasundara, M., Leach, S.T. and Lemberg, D.A. (2009) Defensins and inflammation: The role of defensins in inflammatory bowel disease. Journal of Gastroenterology and Hepatology, 24, 202-208. doi:10.2217/fmb.09.104
|
[19]
|
Zilbauer, M., Jenke, A. and Wenzel, G.. (2010) Expression of human beta-defensins in children with chronic inflamematory bowel disease. Public Library of Science Pathogens, 5, e15389. doi:10.1371/journal.pone.0015389
|
[20]
|
Kohlgraf, K.G., Pingel, L.C., Dietrich, D.E., et al. (2010) Defensins as anti-inflammatory compounds and mucosal adjuvants. Future Microbiology, 5, 99-113. doi:10.2217/fmb.09.104
|
[21]
|
Doss, M., White, M.R., Tecle, T., et al. (2010) Human defensins and LL-37 in mucosal immunity. Journal of Leukocyte Biology, 87, 79-92. doi:10.1189/jlb.0609382
|
[22]
|
Bocchinfuso, G., Palleschi, A., Orioni, B., et al. (2009) Different mechanisms of action of antimicrobial peptides: Insights from fluorescence spectroscopy experiments and molecular dynamics simulations. Journal of Peptide Science, 15, 550-558. doi:10.1002/psc.1144
|
[23]
|
Cunliffe, R.N. (2003) Alpha-defensins in the gastrointestinal tract. Molecular Immunology, 40, 463-467. doi:10.1016/S0161-5890(03)00157-3
|
[24]
|
Wehkamp, J., Schmid, M. and Stange, E.F. (2007) Defensins and other antimicrobial peptides in inflammatory bowel disease. Current Opinion in Gastroenterology, 23, 370-378. doi:10.1097/MOG.0b013e328136c580
|
[25]
|
Cunliffe, R.N., Rose, F.R., Keyte, J., et al. (2001) Human defensin-5 (HD-5) is processed upon Paneth cell granule secretion, and its expression is induced inflammatory bowel disease (IBD). Gut, 48, 176-185. doi:10.1136/gut.48.2.176
|
[26]
|
Ding, J., Chou, Y.Y. and Chang, T.L. (2009) Defensins in viral infections. Journal of Innate Immunity, 1, 413-420. doi:10.1159/000226256
|
[27]
|
Simms, L.A., Doecke, J.D., Walsh, M.D., et al. (2008) Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn’s disease. Gut, 57, 903-910. doi:10.1136/gut.2007.142588
|
[28]
|
Fu, L.B., Yu, J.L. and Liu, W.H. (2011) Biological characteristics of defensin and its disease-resistance genetic engineering. Hereditas, 33, 512-519. doi:10.3724/SP.J.1005.2011.00512
|
[29]
|
Wehkamp, J., Koslowski, M., Wang, G., et al. (2008) Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn’s disease. Mucosal Immunology, 1, 67-74. doi:10.1038/mi.2008.48
|
[30]
|
Rehaume, L.M. and Hancock, R.E. (2008) Neutrophil- derived defensins as modulators of innate immune func- tion. Critical Reviews in Immunology, 28, 185-200.
|
[31]
|
Pazgier, M., Hoover, D.M., Yang, D., et al. (2006) Hu- man beta-defensins. Cellular and Molecular Life Sciences, 63, 1294-1313. doi:10.1007/s00018-005-5540-2
|
[32]
|
Escribese, M.M., Rodriguez-Garcia, M., Sperling, R., et al. (2011) Alpha-defensins 1-3 release by dendritic cells is reduced by estrogen. Reproductive Biology and Endo-crinology, 9, 118. doi:10.1186/1477-7827-9-118
|
[33]
|
Milewski, L., Dziunycz, P., Barcz, E., et al. (2011) Increased levels of human neutrophil peptides 1, 2, and 3 in peritoneal fluid of patients with endometriosis: Association with neutrophils, T cells and IL-8. Journal of Reproductive Immunology, 91, 64-70. doi:10.1016/j.jri.2011.05.008
|
[34]
|
Ouellette, A.J. (2011) Paneth cell α-defensins in enteric innate immunity. Cellular and Molecular Life Sciences, 68, 2215-2229. doi:10.1007/s00018-011-0714-6
|
[35]
|
Chamaillard, M. and Dessein, R. (2011) Defensins couple dysbiosis to primary immunodeficiency in Crohn’s disease. World Journal of Gastroenterology, 17, 567-571. doi:10.3748/wjg.v17.i5.567
|
[36]
|
Wu, Z., Ericksen, B., Tucker, K., et al. (2004) Synthesis and characterization of human alpha-defensins 4-6. The Journal of Peptide Research, 64, 118-125. doi:10.1111/j.1399-3011.2004.00179.x
|
[37]
|
Nagaoka, I., Niyonsaba, F., Tsutsumi-Ishii, Y., et al. (2008) Evaluation of the effect of human beta-defensins on neurophil apoptosis. International Immunology, 20, 543-553. doi:10.1093/intimm/dxn012
|
[38]
|
Ghannam, S., Dejou, C., Pedretti, N., et al. (2010) CCL20 and β-defensin-2 induce arrest of human Th17 cells on inflamed endothelium in vitro under flow conditions. Journal Immunology, 186, 1411-1420. doi:10.4049/jimmunol.1000597
|
[39]
|
Biragyn, A., Coscia, M., Nagashima, K., et al. (2008) Murine beta-defensin 2 promotes TLR-4/My D88-medi- ated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2. Journal of Leukocyte Biology, 83, 998-1008. doi:10.1189/jlb.1007700
|
[40]
|
Droin, N., Hendra, J.B., Ducoroy, P., et al. (2009) Human defensins as cancer biomarkers and antitumour molecules. Journal of Proteomics, 72, 918-927. doi:10.1016/j.jprot.2009.01.002
|
[41]
|
Yadav, P.K., Chen, C. and Liu, Z. (2011) Potential role of NK cells in the pathogenesis of inflammatory bowel disease. Journal of Biomedicine Biotechnology, 2011, Article ID: 348530.
|
[42]
|
Wehkamp, J. and Stange, E.F. (2008) Is there a role for defensins in IBD? Inflammatory Bowel Diseases, 14, 85-87. doi:10.1002/ibd.20698
|
[43]
|
Wehkamp, J., Salzman, N.H., Porter, E., et al. (2005) Reduced Paneth cell α-defensins in ileal Crohn’s disease. Proceeding of the National Academy of Sciences of the USA, 102, 18129-18134. doi:10.1073/pnas.0505256102
|
[44]
|
Balducci, E., Bonucci, A., Picchianti, M., et al. (2011) Structural and functional consequences induced by post-translational modifications in α-defensins. International Journal of Peptides, 2011, Article ID: 594723.
|
[45]
|
Biswas, A., Liu, Y.J., Hao, L., et al. (2010) Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum. Proceeding of the National Academy of Sciences of the USA, 107, 14739-14744. doi:10.1073/pnas.1003363107
|
[46]
|
Wehkamp, J. and Stange, E.F. (2010) Paneth’s disease. Journal of Crohn’s and Colitis, 4, 523-531. doi:10.1016/j.crohns.2010.05.010
|
[47]
|
Zilbauer, M., Jenke, A., Wenzel, G., et al. (2011) Intestinal alpha-defensin expression in pediatric inflammatory bowel disease. Inflammatory Bowel Diseases, 17, 2076-2086. doi:10.1002/ibd.21577
|
[48]
|
You, X.J., Bryant, P.J. and Jurnak, F. (2007) Expression of Wnt pathway components frizzled and disheveled in colon cancer arising in patients with inflammatory bowel disease. Oncology Reports, 18, 691-694.
|
[49]
|
Sato, T., van, Es, J.H. and Snippert, H.J. (2011) Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature, 469, 415-418.
|
[50]
|
Beisner, J., Stange, E.F. and Wehkamp, J. (2010) Paneth cell function-Implications in pediatric Crohn disease. An International Journal of Gastroenterology and Hepatology on Microbes, 2, 47-51. doi:10.4161/gmic.2.1.14649
|
[51]
|
Wehkamp, J., Wang, G., Kübler, I., et al. (2007) The Paneth cell alpha-defensin deficiency of ileal Crohn’s disease is linked to Wnt/Tcf-4. Journal of Immunology, 179, 3109-3118.
|
[52]
|
Kanmura, S., Uto, H., Numata, M., et al. (2009) Human neutrophil peptides 1-3 are useful biomarkers in patients with active ulcerative colitis. Inflammatory Bowel Diseases, 15, 909-917. doi:10.1002/ibd.20854
|
[53]
|
Inaba, Y., Ashida, T., Ito, T., et al. (2010) Expression of the antimicrobial peptide alpha-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice. Inflammatory Bowel Diseases, 16, 1488- 1495. doi:10.1002/ibd.21253
|
[54]
|
Yamaguchi, N., Isomoto, H., Mukae, H., et al. (2009) Concentrations of alpha- and beta-defensins in plasma of patients with inflammatory bowel disease. Inflammation Research, 58, 192-197. doi:10.1007/s00011-008-8120-8
|
[55]
|
Ou, G., Baranov, V., Lundmark, E., et al. (2009) Contribution of intestinal epithelial cells to innate immunity of the human gut—Studies on polarized monolayers of colon carcinoma cells. Scandinavian Journal of Immunology, 69, 150-161. doi:10.1111/j.1365-3083.2008.02208.x
|
[56]
|
Zhang, H.H., Yang, X.M., Xie, Q.M., et al. (2010) The potent adjuvant effects of chicken beta-defensin-1 when genetically fused with infectious bursal disease virus VP2 gene. Veterinary Immunology and Immunopathology, 136, 92-97. doi:10.1016/j.vetimm.2010.02.018
|
[57]
|
Kocsis, A.K., Lakatos, P.L., Somogyvári, F., et al. (2008) Association of beta-defensin 1 single nucleotide polymerphisms with Crohn’s disease. Scandinavian Journal of Gastroenterology, 43, 299-307.
|
[58]
|
Rahman, A., Fahlgren, A., Sitohy, B., et al. (2007) Beta-defensin production by human colonic plasma cells: A new look at plasma cells in ulcerative colitis. Inflammatory Bowel Diseases, 13, 847-855. doi:10.1002/ibd.20141
|
[59]
|
Gutiérrez, A., Holler, E., Zapater, P., et al. (2011) Antimicrobial peptide response to blood translocation of bacterial DNA in Crohn’s disease is affected by NOD2/ CARD15 genotype. Inflammatory Bowel Diseases, 17, 1641-1650.
|
[60]
|
Chamaillard, M. and Dessein, R. (2011) Defensins couple dysbiosis to primary immunodeficiency in Crohn’s disease. World Journal of Gastroenterology, 17, 567-571. doi:10.3748/wjg.v17.i5.567
|
[61]
|
Semple, F., Webb, S., Li, H.N., et al. (2010) Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo. European Journal of Immunology, 40, 1073-1078. doi:10.1002/eji.200940041
|
[62]
|
Chang, Y.Y. and Ouyang, Q. (2008) Expression and significance of mucosal beta-defensin-2, TNFalpha and IL-1beta in ulcerative colitis. The Chinese Journal of Internal Medicine, 47, 11-14.
|
[63]
|
Salzman, N.H., Underwood, M.A. and Bevins, C.L. (2007) Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa. Seminars in Immunology, 19, 70-83. doi:10.1016/j.smim.2007.04.002
|
[64]
|
Aldhous, M.C., Noble, C.L. and Satsangi, J. (2009) Dysregulation of human β-defensin-2 protein in inflammatory bowel disease. Public Library of Science Pathogens One, 4, e6285. doi:10.1371/journal.pone.0006285
|
[65]
|
Gersemann, M., Wehkamp, J., Fellermann, K., et al. (2008) Crohn’s disease-defect in innate defence. World Journal of Gastroenterology, 14, 5499-5503. doi:10.3748/wjg.14.5499
|
[66]
|
Schneider, J.J., Unholzer, A., Schaller, M., et al. (2005) Human defensins. The Journal of Molecular Medicine, 83, 587-595.
|