Rapid decrease of necrotic core after acute myocardial infarction


It is well known that the increase of necrotic core in previous atherosclerotic coronary artery disease is one of the conditions of vulnerable plaque. However, it is not known how fast necrotic core could decrease in a vulnerable plaque. We had 2 patients who had suffered from acute myocardial infarction and had large amount of necrotic core in their culprit lesions at baseline, which decreased markedly within 7 days. Also, they were clinically stable and asymptomatic over 1 year follow-up. It is first report to show mar-kedly decrease of necrotic core amount within only 7 days in culprit lesions of 2 cases of acute myocardial infarction with angiographically minimal lesions.

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Lee, J. , Shin, E. , Kim, S. , Kim, J. , Hwang, J. , Garcia-Garcia, H. and Serruys, P. (2012) Rapid decrease of necrotic core after acute myocardial infarction. World Journal of Cardiovascular Diseases, 2, 95-98. doi: 10.4236/wjcd.2012.22015.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Hiromasa, S., Sachio, K., Tadanori, A., et al. (1999) Histological evaluation of coronary plaque in patients with variant angina: Relationship between vasospasm and neointimal hyperplasia in primary coronary lesions. Journal of the American College of Cardiology, 33, 198-205. doi:10.1016/S0735-1097(98)00520-8
[2] Severi, S., Davies, G., Maseri, A., et al. (1980) Long-Term prognosis of “variant” angina with medical treatment. American Journal of Cardiology, 46, 226-232. doi:10.1016/0002-9149(80)90062-4
[3] Nakamura, M., Takeshita, A. and Nose, Y. (1987) Clinical characteristics associated with myocardial infarction, arrhythmias, and sudden death in patients with vasospastic angina. Circulation, 75, 1110-1116. doi:10.1161/01.CIR.75.6.1110
[4] Maseri, A., L’Abbate, A., Baroldi, G., et al. (1978) Coro- nary vasospasm as a possible cause of myocardial infarction: A conclusion derived from the study of preinfarction angina. New England Journal of Medicine, 299, 1271- 1277. doi:10.1056/NEJM197812072992303
[5] Marzilli, M., Goldstein, S., Trivella, MG., et al. (1980) Some clinical considerations regarding the relation of coronary vasospasm tocoronary atherosclerosis: A hypo- thetical pathogenesis. American Journal of Cardiology, 45, 882-886. doi:10.1016/0002-9149(80)90135-6
[6] Nobuyoshi, M., Tanaka, M., Nosaka, H., et al. (1991) Progression of coronary atherosclerosis: Is coronary spasm related to progression? Journal of the American College of Cardiology, 18, 904-910. doi:10.1016/0735-1097(91)90745-U
[7] Kaski, J.C., Tousuolis, D., McFadden, E., et al. (1992) Variant angina pectoris: Role of coronary spasm in the development of fixed coronary obstructions. Circulation, 85, 619-626.
[8] Ozaki, Y., Keane, D. and Patrick, W.S. (1995) Progression and regression of coronary stenosis in the long-term follow-up of vasospastic angina. Circulation, 92, 2446- 2456.
[9] Thim, T., Hagensen, M.K., Bentzon, J.F. and Folk E. (2008) From vulnerable plaque to atherothrombosis. Journal of Internal Medicine, 263, 506-516. doi:10.1111/j.1365-2796.2008.01947.x
[10] Etsuda, H., Mizuno, K., Arakawa, K., et al. (1993) Angioscopy in variant angina: coronary artery spasm and intimal injury. Lancet, 342, 1322-1324. doi:10.1016/0140-6736(93)92245-O
[11] Kolodgie, F.D., Gold. H.K., Burke, A.P., et al. (2003) Intraplaque hemorrhage and progression of coronary atheroma. New England Journal of Medicine, 349, 2316- 2325. doi:10.1056/NEJMoa035655
[12] Virmani, R., Kolodgie, F.D., Burke, A.P., et al. (2005) Atherosclerotic plaque progression and vulnerability to rupture; angiogenesis as a source of intraplaque hemorrhage. Atherosclerosis, Thrombosis and Vascular Biology, 25, 2054-2061. doi:10.1161/01.ATV.0000178991.71605.18
[13] Prasad, A., Cipher, D.J., Prasad, A., et al. (2008) Repro- ducibility of intravascular ultrasound virtual histology analysis. Cardiovascular Revascularization Medicine, 9, 71-77. doi:10.1016/j.carrev.2007.11.004
[14] Rodriguez-Granillo, G.A., Vaina, S., García-García, H.M., et al. (2006) Reproducibility of intravascular ultrasound radiofrequency data analysis: Implications for the design of longitudinal studies. The International Journal of Cardiovascular Imaging, 22, 621-631. doi:10.1007/s10554-006-9080-0
[15] Hartmann, M., Mattern, E.S., Huisman, J., et al. (2009) Reproducibility of volumetric intravascular ultrasound radiofrequency-based analysis of coronary plaque composition in vivo. International Journal of Cardiovascular Imaging, 25, 13-23. doi:10.1007/s10554-008-9338-9

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