Antibacterial Activity of Pterocarpus osun L. on Multi-Drug Resistant (MDR) Escherichia coli from Wound Infections in Abeokuta, South-West Nigeria


Pterocarpus osun plant has been used overtime in the indigenous system of medicine. In this study, methanol, ethanol and aqueous extracts of leaves of P. osun were examined against five Escherichia coli strains obtained from wounds. Antibacterial effect of the plant leaves, in the concentration of 100 mg/ml, was determined using disc diffusion method. Phytochemical screening of extracts of the leaves revealed the presence of phenols, flavonoids, tannins, terpenoids alkaloids, and glycosides. Leaves extracts of P. osun showed different zones of inhibition to the Escherichia coli isolates in the different solvents used. Results from this study showed that extracts of P.osun had broad spectrum of activity on the tested bacteria.

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Shobayo, B. , Ojo, D. and Agboola, D. (2015) Antibacterial Activity of Pterocarpus osun L. on Multi-Drug Resistant (MDR) Escherichia coli from Wound Infections in Abeokuta, South-West Nigeria. Open Access Library Journal, 2, 1-6. doi: 10.4236/oalib.1101434.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Hutchinson, J., Dalziel, J.M. and Keay, R.W.J. (1958) Floral of West Tropical Africa. Agents for Overseas Government and Administration, London, 531.
[2] Rao, S.P. and Raju, A.J.S. (2002) Pollination Ecology of the Red Sanders Pterocarpus santalinus (Fabaceae), an Endemic and Endangered tree Species. Current Science India, 83, 1144-1148.
[3] Okigbo, R.N., Eme, U.E. and Ogbogu, S. (2008) Biodiversity and Conservation of Medicinal and Aromatic Plants in Africa. Biotechnology and Molecular Biology Reviews, 3, 127-134.
[4] World Health Organization (2003) Traditional Medicine.
[5] Mukherjee, P.K., Maiti, K., Mukherjee, K. and Houghton, P. (2006) Leads from Indian Medicinal Plants with Hypoglycemic Potentials. Journal of Ethnopharmacology, 106, 1-28.
[6] Krishnaveni, K.S. and Rao, J.V. (2000) A New Isoflavoneglucoside from Pterocarpus santalinus. Journal of Asian Natural products Research, 2, 219-223.
[7] Manjunatha, B.K. (2006) Antimicrobial Activity of Pterocarpus santalinus. Indian Journal of Parmaceutical Sciences, 68, 115-116.
[8] Narayan, S., Devi, R.S. and Devi, C.S.S. (2007) Role of Pterocarpus santalinus against Mitochondrial Dysfunction and Membrane Lipid Changes Induced by Ulcerogens in Rat Gastric Mucosa. Chemico-Biological Interactions, 170, 67-75.
[9] Akingbade, O.A., Balogun, S.A., Ojo, D.A., Afolabi, R.O., Motayo, B.O., Okerentugba, P.O. and Okonko, I.O. (2012) Plasmid Profile Analysis of Multidrug Resistant Pseudomonas aeruginosa isolated from Wound Infections in South West Nigeria. World Applied Science Journal, 20, 766-775.
[10] Nwachukwu, N.C., Orji, F.A. and Okike, U.M. (2009) Antibiotic Susceptibility Patterns of Bacterial Isolates from Surgical Wounds in Abia State University Teaching Hospital (ABSUTH), Aba-Nigeria. Research Journal of Medicine and Medical Sciences, 4, 575-579.
[11] Ayton, M. (1985) Wound Care: Wounds That Won’t Heal. Nursing Times, 81, 16-19.
[12] Magiorakos, A.P., Srinivasan, A., Carey, R.B., Carmeli, Y., Falagas, M.E., Giske, C.G., et al. (2011) Multidrug-Resistant, Extensively Drug-Resistant and Pandrug-Resistant Bacteria: An International Expert Proposal for Interim Standard Definitions for Acquired Resistance. Clinical Microbiology and Infectious Diseases, 18, 268-281.
[13] Bartoloni, A., Pallecchi, L., Benedetti, M., Fernandez, C., Vallejos, Y., Guzman, E., et al. (2006) Multidrug-Resistant Commensal Escherichia coli in Children, Peru and Bolivia. Emerging Infectious Diseases, 12, 907-913.
[14] von Baum, H. and Reinhard, M. (2005) Antimicrobial Resistance of Escherichia coli and Therapeutic Implications. International Journal of Medical Microbiology, 295, 503-511.
[15] Aibinu, I., Adenipekun, E. and Odugbemi, T. (2004) Emergence of Quinolone Resistance amongst Escherichia coli Strains Isolated from Clinical Infections in Some Lagos State Hospitals in Nigeria. Nigeria Journal Health Biomedical Science, 3, 73-78.
[16] Celebi, A., Duran, N., Ozturk, F., Acik, L., Aslan, G. and Aslantas, O. (2007) Identification of Clinic Uropathogen Escherichia coli Isolates by Antibiotic Susceptibility, Plasmid and Whole Cell Protein Profiles. Advance Molecular Biology, 1, 31-40.
[17] Kent, P.N., Dixon, D.M., Holland, S.M. and Fauci, A.S. (2008) The Research Agenda of the National Institute of Allergy and Infectious Diseases for Antimicrobial Resistance. The Journal of Infectious Diseases, 197, 1087-1093.
[18] Talukdar, A.D., Choudhary, M.D., Chakraborty, M. and Dutta, B.K. (2010) Phytochemical Screening and TLC Profiling of Plant Extracts Cyathea gigantea and Cyathea brunoniana. Biological and Environmental Sciences, 5, 70-74.
[19] Akueshi, C.O., Kadiri, C.O., Akueshi, E.U., Agina, S.E. and Njurukwem, C. (2002) Antimicrobial Potentials of Hyptis suaveolens Poit (Lamiaceae). Nigerian Journal of Botany, 15, 37-41.
[20] Ebi, G.C. and Ofoefule, S.I. (2000) Antimicrobial Activity of Pterocarpus osun Stems. Fitoterapia, 71, 433-435.
[21] Farooq, A., Sajid, L., Muhammad, A. and Anwarul, H.G. (2007) Moringa oleifera: A Food Plant with Multiple Medicinal Uses. Phytotherapy Research, 21, 17-25.
[22] Burjaq, S.Z. and Shehabi, A.A. (2013) Fresh Leafy Green Vegetables Associated with Multidrug Resistant E.coli. The International Arabic Journal of Antimicrobial Agents, 3, 3.
[23] Akingbade, O.A., Damola, A.B., Shobayo, B.I., Nwanze, J.C. and Okonko, I.O. (2014) Multi-Drug Resistant (MDR) Escherichia coli among Children Suffering from Diarrhea Infections in Abeokuta, Nigeria. Researcher, 6, 11-17.
[24] Gabriel, A.F. and Onigbanjo, H.O. (2010) Phytochemical and Antimicrobial Screening of the Stem Bark Extracts of Pterocarpus erinaceus (Poir). Nigerian Journal of Basic and Applied Sciences, 18, 1-5.
[25] Sharma, N., Kachhawa, J.B.S., Tyagi, S., Gupta, R.S. and Sharma, K.K. (2012) In Vitro Evaluation of Antibacterial Activity of Pterocarpus marsupium Roxb. International Journal of Pharmacy and Pharmaceutical Sciences, 4, 67-68.
[26] Zee-Cheng, R.K. (1997) Anticancer Research on Loranthaceae Plants. Drugs Future, 22, 519-530.
[27] Tsuchiya, H., Sato, M., Miyazaki, T., Fujiwara, S., Tanigaki, S., Ohyama, M., Tanaka, T. and Linuma, M. (1996) Comparative Study on the Antibacterial Activity of Phytochemical Flavanones against Methicillin-Resistant Staphylococcus aureus. Journal of Ethnopharmarcology, 50, 27-34.

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