Nanoscale Stiffness Distribution in Bone Metastasis

Ludovic Richert¹, Laetitia Keller^2,3, Quentin Wagner^2,3, Fabien Bornert^2,3,4, Catherine Gros^2,3,4, Sophie Bahi^2,3,4, François Clauss^2,3,4, William Bacon^2,3,4, Philippe Clézardin⁵, Nadia Benkirane-Jessel^2,3,4, Florence Fioretti^2,3,4

¹Centre National de la Recherche Scientifique (CNRS), UMR, Faculté de Pharmacie de l’Université de Strasbourg (UdS), Illkirch, France.
²Institut National de la Santé et de la Recherche Médicale (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR, Faculté de Médecine de l’Université de Strasbourg and FMTS, Strasbourg, France.
³Faculté de Chirurgie Dentaire de l’Université de Strasbourg (UdS), Strasbourg, France.
⁴Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
⁵Institut National de la Santé et de la Recherche Médicale (INSERM), UMR, Faculté de Médecine Laënnec de l’Université Claude Bernard Lyon 1, Lyon, France.

DOI: 10.4236/wjnse.2015.54023                

Abstract

Nanomechanical heterogeneity is expected to have an effect on elasticity, injury and bone remodelling. In normal bone, we have two types of cells (osteoclasts and osteoblasts) working together to maintain existing bone. Bone cancers can produce factors that make the osteoclasts work harder. This means that more bone is destroyed than rebuilt, and leads to weakening of the affected bone. We report here the first demonstration of the nanoscale stiffness distribution in bone metastases before and after treatment of animals with the bisphosphonate Risedronate, a drug which is currently used for the treatment of bone metastases in patients with advanced cancers. The strategy used here is applicable to a wide class of biological tissues and may serve as a new reflection for biologically inspired scaffolds technologies.

Keywords

Bone Metastasis, Stiffness, Risedronate

Conflicts of Interest

The authors declare no conflicts of interest.

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