Nanoscale Stiffness Distribution in Bone Metastasis
Ludovic Richert1, Laetitia Keller2,3, Quentin Wagner2,3, Fabien Bornert2,3,4, Catherine Gros2,3,4, Sophie Bahi2,3,4, François Clauss2,3,4, William Bacon2,3,4, Philippe Clézardin5, Nadia Benkirane-Jessel2,3,4, Florence Fioretti2,3,4
1Centre National de la Recherche Scientifique (CNRS), UMR, Faculté de Pharmacie de l’Université de Strasbourg (UdS), Illkirch, France.
2Institut National de la Santé et de la Recherche Médicale (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR, Faculté de Médecine de l’Université de Strasbourg and FMTS, Strasbourg, France.
3Faculté de Chirurgie Dentaire de l’Université de Strasbourg (UdS), Strasbourg, France.
4Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
5Institut National de la Santé et de la Recherche Médicale (INSERM), UMR, Faculté de Médecine Laënnec de l’Université Claude Bernard Lyon 1, Lyon, France.
DOI: 10.4236/wjnse.2015.54023   PDF   HTML   XML   4,482 Downloads   5,449 Views   Citations


Nanomechanical heterogeneity is expected to have an effect on elasticity, injury and bone remodelling. In normal bone, we have two types of cells (osteoclasts and osteoblasts) working together to maintain existing bone. Bone cancers can produce factors that make the osteoclasts work harder. This means that more bone is destroyed than rebuilt, and leads to weakening of the affected bone. We report here the first demonstration of the nanoscale stiffness distribution in bone metastases before and after treatment of animals with the bisphosphonate Risedronate, a drug which is currently used for the treatment of bone metastases in patients with advanced cancers. The strategy used here is applicable to a wide class of biological tissues and may serve as a new reflection for biologically inspired scaffolds technologies.

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Richert, L. , Keller, L. , Wagner, Q. , Bornert, F. , Gros, C. , Bahi, S. , Clauss, F. , Bacon, W. , Clézardin, P. , Benkirane-Jessel, N. and Fioretti, F. (2015) Nanoscale Stiffness Distribution in Bone Metastasis. World Journal of Nano Science and Engineering, 5, 219-228. doi: 10.4236/wjnse.2015.54023.

Conflicts of Interest

The authors declare no conflicts of interest.


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