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OJMI> Vol.5 No.4, December 2015
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Cerebral Microbleeds Identified by Susceptibility-Weighted Imaging in Two Cases of Fabry Disease without Neurological Symptoms

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DOI: 10.4236/ojmi.2015.54024    2,986 Downloads   3,447 Views   Citations
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Mineka Yamazoe1, Masayuki Maeda2*, Maki Umino1, Hidekazu Tomimoto3, Hajime Sakuma1


1Department of Radiology, School of Medicine, Mie University, Mie, Japan.
2Department of Advanced Diagnostic Imaging, School of Medicine, Mie University, Mie, Japan.
3Department of Neurology, School of Medicine, Mie University, Mie, Japan.


Cerebrovascular disease is one of the fatal causes of Fabry disease (FD). Brain magnetic resonance imaging findings typically show lacunar infarcts in young patients with FD, but brain hemorrhages in FD are rarely reported. We report two cases of FD focusing on cerebral microbleeds (CMBs). Susceptibility-weighted imaging (SWI) and T2*-weighted imaging reveal several lobar and deep CMBs in two patients with no medical history of stroke symptoms, hypertension, and anticoagulant/antiplatelet treatment. SWI can detect a greater number of CMBs than T2*-weighted imaging. Thus, SWI is an excellent tool for identifying underlying CMBs in FD.


Fabry Disease, Magnetic Resonance Imaging, Susceptibility-Weighted Imaging, Cerebral Microbleeds

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Yamazoe, M. , Maeda, M. , Umino, M. , Tomimoto, H. and Sakuma, H. (2015) Cerebral Microbleeds Identified by Susceptibility-Weighted Imaging in Two Cases of Fabry Disease without Neurological Symptoms. Open Journal of Medical Imaging, 5, 194-198. doi: 10.4236/ojmi.2015.54024.

Conflicts of Interest

The authors declare no conflicts of interest.


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