Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response

Taryn G. Aubrecht; Zachary M. Weil; Bachir Abi Salloum; Maria Eugenia Ariza; Marshall Williams; Brenda Reader; Ronald Glaser; John Sheridan; Randy J. Nelson

doi:10.4236/jbbs.2015.511049

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Journal of Behavioral and Brain Science > Vol.5 No.11, October 2015

Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response ()

Taryn G. Aubrecht^1*, Zachary M. Weil¹, Bachir Abi Salloum¹, Maria Eugenia Ariza², Marshall Williams², Brenda Reader³, Ronald Glaser^2,3, John Sheridan^3,4, Randy J. Nelson¹

¹Departments of Neuroscience, The Ohio State University, Columbus, OH, USA.
²Molecular Virology, Immunology & Medical Genetics, The Ohio State University, Columbus, OH, USA.
³Institute of Behavioral Medicine Research, Wexner Medical Center, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
⁴Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.

DOI: 10.4236/jbbs.2015.511049 PDF HTML XML 4,173 Downloads 4,594 Views Citations

Abstract

Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome. Stress is known to influence the immune system and can exacerbate the sickness response. Although a role for psychological stress in the sickness response, particularly in combination with EBV-encoded deoxyuridine triphosphate nucleotidohydrolase (dUTPase) has been established, and the role of physical stressors in these interactions remains unspecified. In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection. We hypothesize that a chronic physical stressor will exacerbate the sickness response following EBV-encoded dUTPase injection. To test this hypothesis mice receive daily injections of EBV-encoded dUTPase or vehicle and are subjected to 15 min of swim stress each day for 14 days or left unmanipulated. On the final evening of injections mice undergo behavioral testing. EBV-encoded dUTPase injection alone produces some sickness behaviors. The physical swimming stress does not alter the sickness response.

Keywords

Epstein-Barr Virus, Swim Stress, Sickness Response

Share and Cite:

Aubrecht, T. , Weil, Z. , Salloum, B. , Ariza, M. , Williams, M. , Reader, B. , Glaser, R. , Sheridan, J. and Nelson, R. (2015) Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response. Journal of Behavioral and Brain Science, 5, 513-523. doi: 10.4236/jbbs.2015.511049.

Conflicts of Interest

The authors declare no conflicts of interest.

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