Malignant Extragastrointestinal Neuroectodermal Tumor Located at Right Cervical Region

Nil Çomunoğlu; Sergülen Dervişoğlu; Bilge Başkır Elçin; Gonca Ayşe Tekant; Hilmi Apak

doi:10.4236/ojpathology.2015.54017

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OJPathology> Vol.5 No.4, October 2015

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Malignant Extragastrointestinal Neuroectodermal Tumor Located at Right Cervical Region

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DOI: 10.4236/ojpathology.2015.54017 3,425 Downloads 3,912 Views

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Nil Çomunoğlu¹, Sergülen Dervişoğlu¹, Bilge Başkır Elçin¹, Gonca Ayşe Tekant², Hilmi Apak³

Affiliation(s)

¹Department of Pathology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
²Department of Pediatric Surgery, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
³Department of Pediatric Hematooncology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.

ABSTRACT

Malignant Gastrointestinal Neuroectodermal Tumor (GNET) is a recently described rare malignant neoplasm, resembling “clear cell sarcoma of tendons and aponeuroses” morphologically, immunohistochemically and molecular pathologically. We will describe a case of soft tissue sarcoma located at right cervical region of a 9-year-old male patient, mimicking malignant GNET, which can be considered as extragastrointestinal counterpart of this tumor. These tumors have poor prognosis. This is unique, possibly the first case of a soft tissue sarcoma resembling GNET.

KEYWORDS

Gastrointestinal Neuroectodermal Tumor, Clear Cell Sarcoma, S-100 Protein

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Çomunoğlu, N. , Dervişoğlu, S. , Elçin, B. , Tekant, G. and Apak, H. (2015) Malignant Extragastrointestinal Neuroectodermal Tumor Located at Right Cervical Region. Open Journal of Pathology, 5, 125-128. doi: 10.4236/ojpathology.2015.54017.

References

[1]	Enzinger, F.M. (1965) Clear-Cell Sarcoma of Tendons and Aponeuroses. An Analysis of 21 Cases. Cancer, 18, 1163-1174.

[2]	Chung, E.B. and Enzinger, F.M. (1983) A Reassessment of Clear Cell Sarcoma. The American Journal of Clinical Pathology, 7, 405-413. http://dx.doi.org/10.1097/00000478-198307000-00003

[3]	Antonescu, C.R. (2013) Clear Cell Sarcoma of Soft Tissue. In: Fletcher, C.D.M., Bridge, J.A., Hoge-ncloorn, P.C.W. and Mertens, F., Eds., WHO Classification of Tumours of Soft Tissue and Bone, 4th Edition, IARC Press, Lyon, 221-222.

[4]	Stockman, D.L., Miettinen, M., Suster, S., Spagnolo, D., Dominguez-Malagon, H., Hornick, J.L., Adsay, V., Chou, P.M., Amanuel, B., Vantuinen, P. and Zambrano, E.V. (2012) Malignant Gastrointestinal Neuroectodermal Tumor: Clinicopathologic, Immunohistochemical, Ultrastructural, and Molecular Analysis of 16 Cases with a Reappraisal of Clear Cell Sarcoma-Like Tumors of the Gastrointestinal Tract. The American Journal of Surgical Pathology, 36, 857-868. http://dx.doi.org/10.1097/PAS.0b013e31824644ac

[5]	Goldblum, J.R., Folpe, A.L. and Weiss, S.W. (2014) Clear Cell Sarcoma of Tendon and Aponeurosis. In: Goldblum, J.R., Folpe, A.L. and Weiss, S.W., Eds., Soft Tissue Tumors, Elsevier Saunders, Philadelphia, 886-894.

[6]	Zambrano, E., Reyes-Mugica, M., Franchi, A. and Rosai, J. (2003) An Osteoclast-Rich Tumor of the Gastrointestinal Tract with Features Resembling Clear Cell Sarcoma of Soft Parts: Reports of 6 Cases of a GIST Simulator. International Journal of Surgical Pathology, 11, 75-81. http://dx.doi.org/10.1177/106689690301100202

[7]	Kong, J., Li, N., Wu, S., Guo, X., Gu, C. and Feng, Z. (2014) Malignant Gastrointestinal Neuro-ectodermal Tumor: A Case Report and Review of the Literature. Oncology Letters, 8, 2687-2690.

[8]	Thway, K., Judson, I. and Fisher, C. (2014) Clear Cell Sarcoma-Like Tumor of the Gastrointestinal Tract, Presenting as a Second Malignancy after Childhood Hepatoblastoma. Case Reports in Medicine, 2014, Article ID: 984369, 6 p. http://dx.doi.org/10.1155/2014/984369

[9]	Yegen, G., Güllüoglu, M., Mete, O., Onder, S. and Kapran, Y. (2015) Clear Cell Sarcoma-Like Tumor of the Gastrointestinal Tract: A Case Report and Review of the Literature. International Journal of Surgical Pathology, 23, 61-67. http://dx.doi.org/10.1177/1066896914547046