CNVs Associated with Susceptibility to Cancers: A Mini-Review


Copy number variations (CNVs) that are frequent in genome influence on susceptibility of various diseases including cancers. The present mini-review focuses on CNVs associated with susceptibility to the cancers. Since CNVs are different between cancer types, the analysis of the specific CNV makes it possible to estimate the susceptibility to the cancers of interest in individuals. Although it is true that available data on CNVs associated with cancer susceptibility are limited at present, accumulation of the data is accelerated with the research progression of CNVs in near future. Information on CNVs associated with cancer susceptibility is useful for not only cancer research but also personalized healthcare including cancer prevention.

Share and Cite:

Furuya, T. , Suehiro, Y. , Namiki, Y. and Sasaki, K. (2015) CNVs Associated with Susceptibility to Cancers: A Mini-Review. Journal of Cancer Therapy, 6, 413-422. doi: 10.4236/jct.2015.65044.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Gamazon, E.R., Huang, R.S., Dolan, M.E. and Cox, N.J. (2011) Copy Number Polymorphisms and Anticancer Pharmacogenomics. Genome Biology, 12, R46.
[2] Quigley, D. and Balmain, A. (2009) Systems Genetics Analysis of Cancer Susceptibility: From Mouse Modelsto Humans. Nature Reviews Genetics, 10, 651-657.
[3] Borecki, I.B. and Province, M.A. (2008) Linkage and Association: Basic Concepts. Advances in Genetics, 60, 51-74.
[4] Galvan, A., Ioannidis, J.P. and Dragani, TA. (2010) Beyond Genome-Wide Association Studies: Genetic Heterogeneity and Individual Predisposition to Cancer. Trends in Genetics, 26,132-141.
[5] Czene, K., Lichtenstein, P. and Hemminki, K. (2002) Environmental and Heritable Causes of Cancer among 9.6 Million Individuals in the Swedish Family-Cancer Database. International Journal of Cancer, 99, 260-266.
[6] Lichtenstein, P., Holm, N.V., Verkasalo, P.K., Iliadou, A., Kaprio, J., Koskenvuo, M., Pukkala, E., Skytthe, A. and Hemminki, K. (2000) Environmental and Heritable Factors in the Causation of Cancer—Analyses of Cohorts of Twins from Sweden, Denmark, and Finland. The New England Journal of Medicine, 343, 78-85.
[7] Meunier, C., Van Der Kraak, L., Turbide, C., Groulx, N., Labouba, I., Cingolani, P., Blanchette, M., Yeretssian, G., Mes-Masson, A.M., Saleh, M., Beauchemin, N. and Gros. P. (2013) Positional Mapping and Candidate Gene Analysis of the Mouse Ccs3 Locus That Regulates Differential Susceptibility to Carcinogen-Induced Colorectal Cancer. PLoS One, 8, e58733.
[8] Zhang, B., Beeghly-Fadiel, A., Long, J. and Zheng, W. (2011) Genetic Variants Associated with Breast-Cancer Risk: Comprehensive Research Synopsis, Meta-Analysis, and Epidemiological Evidence. The Lancet Oncology Journal, 12, 477-488.
[9] Choy, K., Setlur, S., Lee, C. and Lau, T. (2010) The Impact of Human Copy Number Variation on a New Era of Genetic Testing. BJOG, 117, 391-397.
[10] Kim, H.C., Lee, J.Y., Sung, H., Choi, J.Y., Park, S.K., Lee, K.M., Kim, Y.J., Go, M.J., Li, L., Cho, Y.S., Park, M., Kim, D.J., Oh, J.H., Kim, J.W., Jeon, J.P., Jeon, S.Y., Min, H., Kim, H.M., Park, J., Yoo, K.Y., Noh, D.Y., Ahn, S.H., Lee, M.H., Kim, S.W., Lee, J.W., Park, B.W., Park, W.Y., Kim, E.H., Kim, M.K., Han, W., Lee, S.A., Matsuo, K., Shen, C.Y., Wu, P.E., Hsiung, C.N., Lee, J.Y., Kim, H.L., Han, B.G. and Kang, D. (2012) A Genome-Wide Association Study Identifies a Breast Cancer Risk Variant in ERBB4 at 2q34: Results from the Seoul Breast Cancer Study. Breast Cancer Research, 14, R56.
[11] Zheng, Y., Ogundiran, T.O., Falusi, A.G., Nathanson, K.L., John, E.M., Hennis, A.J., Ambs, S., Domchek, S.M., Rebbeck, T.R., Simon, M.S., Nemesure, B., Wu, S.Y., Leske, M.C., Odetunde, A., Niu, Q., Zhang, J., Afolabi, C., Gamazon, E.R., Cox, N.J., Olopade, C.O., Olopade, O.I. and Huo, D. (2013) Fine Mapping of Breast Cancer Genome-Wide Association Studies Loci in Women of African Ancestry Identifies Novel Susceptibility Markers. Carcinogenesis, 34, 1520-1528.
[12] Dong, L.M., Potter, J.D., White, E., Ulrich, C.M., Cardon, L.R. and Peters, U. (2008) Genetic Susceptibility to Cancer: The Role of Polymorphisms in Candidate Genes. Journal of the American Medical Association, 299, 2423-2436.
[13] Sebat, J., Lakshmi, B., Roge, J., Alexander, J., Young, J., Lundin, P., Manér, S., Massa, H., Walker, M., Chi, M., Navin, N., Lucito, R., Healy, J., Hicks, J., Ye, K., Reiner, A., Gilliam, T.C., Trask, B., Patterson, N., Zetterberg, A. and Wigler, M. (2004) Large-Scale Copy Number Polymorphism in the Human Genome. Science, 305, 525-528.
[14] Iafrate, A.J., Feuk, L., Rivera, M.N., Listewnik, M.L., Donahoe, P.K., Qi, Y., Scherer, S.W. and Lee, C. (2004) Detection of Large-Scale Variation in the Human Genome. Nature Genetics, 36, 949-951.
[15] Olsson, L.M. and Holmdahl, R. (2012) Copy Number Variation in Autoimmunity—Importance Hidden in Complexity? European Journal of Immunology, 42, 1969-1976.
[16] Malhotra, D. and Sebat, J. (2012) CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics. Cell, 148, 1223-1241.
[17] Almal, S.H. and Padh, H. (2012) Implications of Gene Copy-Number Variation in Health and Diseases. Journal of Human Genetics, 57, 6-13.
[18] Kuiper, R.P., Ligtenberg, M.J., Hoogerbrugge, N. and Geurts van Kessel, A. (2010) Germline Copy Number Variation and Cancer Risk. Current Opinion in Genetics Development, 20, 282-289.
[19] Karyadi, D.M., Karlins, E., Decker, B., vonHoldt, B.M., Carpintero-Ramirez, G., Parker, H.G., Wayne, R.K. and Ostrander, E.A. (2013) A Copy Number Variant at the KITLG Locus Likely Confers Risk for Canine Squamous Cell Carcinoma of the Digit. PLoS Genetics, 9, e1003409.
[20] Luo, J., Yu, Y., Mitra, A., Chang, S., Zhang, H.M., Liu, G., Yang, N. and Song, J.Z. (2013) Genome-Wide Copy Number Variant Analysis in Inbred Chickens Lines with Different Susceptibility to Marek’s Disease. Genes, Genomes, Genetics, 3, 217-223.
[21] Feuk, L., Scherer, S.W. and Carson, A.R. (2008) Structural Variation in the Human Genome. Nature Reviews Genetics, 7, 85-97.
[22] Conrad, D.F., Pinto, D., Redon, R., Feuk, L., Gokcumen, O., Zhang, Y., Aerts, J., Andrews, T.D., Barnes, C., Campbell, P., Fitzgerald, T., Hu, M., Ihm, C.H., Kristiansson, K., Macarthur, D.G., Macdonald, J.R., Onyiah, I., Pang, A.W., Robson, S., Stirrups, K., Valsesia, A., Walter, K., Wei, J., Carter, N.P., Lee, C., Scherer, S.W. and Hurles, M.E. (2010) Origins and Functional Impact of Copy Number Variation in the Human Genome. Nature, 464, 704-712.
[23] Valsesia, A., Macé, A., Jacquemont, S., Beckmann, J.S. and Kutalik, Z. (2013) The Growing Importance of CNVs: New Insights for Detection and Clinical Interpretation. Frontiers in Genetics, 4, 92.
[24] Bailey, J.A. and Eichler, E.E. (2006). Primate Segmental Duplications: Crucibles of Evolution, Diversity and Disease. Nature Reviews Genetics 7, 552-564.
[25] Juan, D., Rico, D., Marques-Bonet, T., Fernández-Capetillo, O. and Valencia, A. (2013) Late-Replicating CNVs as a Source of New Genes. Biology Open, 2, 1402-1411.
[26] Carter, N.P. (2007) Methods and Strategies for Analyzing Copy Number Variation Using DNA Microarrays. Nature Genetics, 39, S16-S21.
[27] McCarroll, S.A., Kuruvilla, F.G., Korn, J.M., Cawley, S., Nemesh, J., Wysoker, A., Shapero, M.H., de Bakker, P.I., Maller, J.B., Kirby, A., Elliott, A.L., Parkin, M., Hubbell, E., Webster, T., Mei, R., Veitch, J., Collins, P.J., Handsaker, R., Lincoln, S., Nizzari, M., Blume, J., Jones, K.W., Rava, R., Daly, M.J., Gabriel, S.B. and Altshuler, D. (2008) Integrated Detection and Population-Genetic Analysis of SNPs and Copy Number Variation. Nature Genetics, 40, 1166-1174.
[28] Goetz, M.P., Knox, S.K., Suman, V.J., Rae, J.M., Safgren, S.L., Ames, M.M., Visscher, D.W., Reynolds, C., Couch, F.J., Lingle, W.L., Weinshilboum, R.M., Fritcher, E.G., Nibbe, A.M., Desta, Z., Nguyen, A., Flockhart, D.A., Perez, E.A. and Ingle, J.N. (2007) The Impact of Cytochrome P450 2D6 Metabolism in Women Receiving Adjuvant Tamoxifen. Breast Cancer Research and Treatment, 101, 113-121.
[29] Gasche, Y., Daali, Y., Fathi, M., Chiappe, A., Cottini, S., Dayer, P. and Desmeules, J. (2004) Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism. The New England Journal of Medicine, 351, 2827-2831.
[30] Malaiyandi, V., Sellers, E.M. and Tyndale, R.F. (2005) Implications of CYP2A6 Genetic Variation for Smoking Behaviors and Nicotine Dependence. Clinical Pharmacology & Therapeutics, 77, 145-158.
[31] Eichler, E.E. (2008) Copy Number Variation and Human Disease. Nature Education, 1, 1.
[32] Merikangas, A.K., Corvin, A.P. and Gallagher, L. (2009) Copy-Number Variants in Neurodevelopmental Disorders: Promises and Challenges. Trends in Genetics, 25, 536-544.
[33] Bruder, C.E., Piotrowski, A., Gijsbers, A.A., Andersson, R., Erickson, S., Diaz de Stahl, T., Menzel, U., Sandgren, J., von Tell, D., Poplawski, A., Crowley, M., Crasto, C., Partridge, E.C., Tiwari, H, Allison, D.B., Komorowski, J., van Ommen, G.J., Boomsma, D.I., Pedersen, N.L., den Dunnen, J.T., Wirdefeldt, K. and Dumanski, J.P. (2008) Phenotypically Concordant and Discordant Monozygotic Twins Display Different DNA Copy-Number-Variation Profiles. The American Journal of Human Genetics, 82, 763-771.
[34] Liang, Q., Conte, N., Skarnes, W.C. and Bradley, A. (2006) Extensive Genomic Copy Number Variation in Embryonic Stem Cells. Proceedings of the National Academy of Sciences of the United States of America, 105, 17453-17456.
[35] Abyzov, A., Mariani, J., Palejev, D., Zhang, Y., Haney, M.S., Tomasini, L., Ferrandino, A.F., Rosenberg Belmaker, L.A., Szekely, A., Wilson, M., Kocabas, A., Calixto, N.E., Grigorenko, E.L., Huttner, A., Chawarska, K., Weissman, S., Urban, A.E., Gerstein, M. and Vaccarino, F.M. (2012) Somatic Copy Number Mosaicism in Human Skin Revealed by Induced Pluripotent Stem Cells. Nature, 492, 438-442.
[36] Poduri, A., Evrony, G.D., Cai, X. and Walsh, C.A. (2013) Somatic Mutation, Genomic Variation, and Neurological Disease. Science, 341, Article ID: 1237758.
[37] Carvalho, C.M., Pehlivan, D., Ramocki, M.B., Fang, P., Alleva, B., Franco, L.M., Belmont, J.W., Hastings, P.J. and Lupski, J.R. (2013) Replicative Mechanisms for CNV Formation Are Error Prone. Nature Genetics, 45, 1319-1326.
[38] Krepischi, A.C.V., Pearson, P.L. and Rosenberg, C. (2012) Germline Copy Number Variations and Cancer Predisposition. Future Oncology, 8, 441-450.
[39] Suehiro, Y., Okada, T., Shikamoto, N., Zhan, Y., Sakai, K., Okayama, N., Nishioka, M., Furuya, T., Oga, A., Kawauchi, S., Maeda, N., Tamesa, M., Nagashima, Y., Yamamoto, S., Oka, M., Hinoda, Y. and Sasaki, K. (2013) Germline Copy Number Variations Associated with Breast Cancer Susceptibility in a Japanese Population. Tumor Biology, 34, 947-952.
[40] Demichelis, F. and Stanford, J.L. (2015) Genetic Predisposition to Prostate Cancer: Update and Future Perspectives. Urologic Oncology, 33, 75-84.
[41] Edsgard, D., Dalgaard, M.D., Weinhold, N., Wesolowska-Andersen, A., Rajpert-De Meyts, E., Ottesen, A.M., Juul, A., Skakkebaek, N.E., Skot Jensen. T., Gupta. R., Leffers, H. and Brunak, S. (2013) Genome-Wide Assessment of the Association of Rare and Common Copy Number Variations to Testicular Germ Cell Cancer. Frontiers in Endocrinology, 4, 2.
[42] Krepischi, A.C., Capelli, L.P., Silva, A.G., de Araújo, E.S.S., Pearson, P.L., Heck, B., da Costa, C.M.L., de Camargo, B. and Rosenberg, C. (2014) Large Germline Copy Number Variations as Predisposing Factor in Childhood Neoplasms. Future Oncology, 10, 1627-1633.
[43] Hopman, S., Merks, J., Eussen, H., Douben, H., Snijder, S., Hennekam, R., de Klein, A. and Caron, H. (2013) Structural Genome Variations in Individuals with Childhood Cancer and Tumour Predisposition Syndromes. European Journal of Cancer, 49, 2170-2178.
[44] Yu, K., Fan, J., Ding, X., Li, C., Wang, J., Xiang, Y. and Wang, Q.S. (2014) Association Study of a Functional Copy Number Variation in the WWOX Gene with Risk of Gliomas among Chinese People. International Journal of Cancer, 135, 1687-1691.
[45] Sridhar, S., Al-Moallem, B., Kamal, H., Terrile, M. and Stallings, R.L. (2013) New Insights into the Genetics of Neuroblastoma. Molecular Diagnosis & Therapy, 17, 63-69.
[46] Diskin, S.J. (2009) Copy Number Variation at 1q21.1 Associated with Neuroblastoma. Nature, 459, 987-991.
[47] Capasso, M. and Diskin, S.J. (2010) Genetics and Genomics of Neuroblastoma. Cancer Genetics, 155, 65-84.
[48] Tse, K.P., Su, W.H., Yang, M.L., Cheng, H.Y., Tsang, N.M., Chang, K.P., Hao, S.P., Shugart, Y.Y. and Chang. Y.S. (2011) A Gender-Specific Association of CNV at 6p21.3 with NPC Susceptibility. Human Molecular Genetics, 20, 2889-2896.
[49] Sun, Y.L., Shi, N., Lu, H.Z., Zhang, J.Q., Ma, Y.L., Qiao, Y.Y., Mao, Y.H., Jia, K., Han, L.F., Liu, F., Li, H.X., Lin, Z.W., Li, X.M. and Zhao, X.H. (2014) ABCC4 Copy Number Variation Is Associated with Susceptibility to Esophageal Squamous Cell Carcinoma. Carcinogenesis, 35, 1941-1950.
[50] Tsai, P.C., Huang, S.W., Tsai, H.L., Ma, C.J., Hou, M.F., Yang, I.P., Wang, Y.S., Juo, S.H. and Wang, J.Y. (2014) The Association between DNA Copy Number Aberrations at Chromosome 5q22 and Gastric Cancer. PLoS ONE, 9, e106624.
[51] Angstadt, A.Y., Berg, A., Zhu, J.J., Miller, P., Hartman, T.J., Lesko, S.M., Muscat, J.E., Lazarus, P. and Gallagher, C.J. (2013) The Effect of Copy Number Variation in the Phase II Detoxification Genes UGT2B17 and UGT2B28 on Colorectal Cancer Risk. Cancer, 119, 2477-2485.
[52] Yang, R.X., Chen, B.W., Pfutze, K., Buch, S., Steinke, V., Holinski-Feder, E., Stocker, S., von Schonfels, W., Becker, T., Schackert, H.K., Royer-Pokora, B., Kloor, M., Schmiegel, W.H., Buttner, R., Engel, C., LascorzPuertolas, J., Forsti, A., Kunkel, N., Bugert, P., Schreiber, S., Krawczak, M., Schafmayer, C., Propping, P., Hampe, J., Hemminki, K. and Burwinkel, B. (2014) Genome-Wide Analysis Associates Familial Colorectal Cancer with Increases in Copy Number Variations and a Rare Structural Variation at 12p12.3. Carcinogenesis, 35, 315-323.
[53] Berg, M., Agesen, T.H., Thiis-Evensen, E., INFAC-Study Group, Merok, M.A., Teixeira, M.R., Vatn, M.H., Nesbakken, A., Skotheim, R.I. and Lothe, R.A. (2010) Distinct High Resolution Genome Profiles of Early Onset and Late Onset Colorectal Cancer Integrated with Gene Expression Data Identify Candidate Susceptibility Loci. Molecular Cancer, 9, 100.
[54] Huang, L.M., Yu, D.K., Wu, C., Zhai, K., Jiang, G.L., Cao, G.W., Wang, C.Y., Liu, Y., Sun, M.H., Li, Z.S., Tan, W. and Lin, D.X. (2012) Copy Number Variation at 6q13 Functions as a Long-Range Regulator and Is Associated with Pancreatic Cancer Risk. Carcinogenesis, 33, 94-100.
[55] Fanale, D., Iovanna, J.L., Calvo, E.L., Berthezene, P., Belleau, P., Dagorn, J.C., Bronte, G., Cicero, G., Bazan, V., Rolfo, C., Santini, D. and Russo, A. (2014) Germline Copy Number Variation in the YTHDC2 Gene: Does It Have a Role in Finding a Novel Potential Molecular Target Involved in Pancreatic Adenocarcinoma Susceptibility? Expert Opinion on Therapeutic Targets, 18, 841-850.
[56] Willis, J.A., Mukherjee, S., Orlow, I., Viale, A., Offit, K., Kurtz, R.C., Olson, S.H. and Klein, R.J. (2014) Genome-Wide Analysis of the Role of Copy-Number Variation in Pancreatic Cancer Risk. Frontiers in Genetics, 5, 29.
[57] Liu, B., Yang, L., Huang, B.F., Cheng, M., Wang, H., Li, Y.Y., Huang, D.S., Zheng, J., Li, Q.C., Zhang, X., Ji, W.D., Zhou, Y.F. and Lu, J.C. (2012) A Functional Copy-Number Variation in MAPKAPK2 Predicts Risk and Prognosis of Lung Cancer. The American Journal of Human Genetics, 91, 384-390.
[58] Yang, L., Liu, B., Huang, B.F., Deng, J.Q., Li, H.B., Yu, B.L., Qiu, F.M., Cheng, M., Wang, H., Yang, R.R., Yang, X.R., Zhou, Y.F. and Lu, J.C. (2013) A Functional Copy Number Variation in the WWOX Gene Is Associated with Lung Cancer Risk in Chinese. Human Molecular Genetics, 22, 1886-1894.
[59] Yang, L., Lu, X.X., Qiu, F.M., Fang, W.X., Zhang, L.S., Huang, D.S., Xie, C.L., Zhong, N.S., Ran, P.X., Zhou, Y.F. and Lu, J.C. (2014) Duplicated Copy of CHRNA7 Increases Risk and Worsens Prognosis of COPD and Lung Cancer. European Journal of Human Genetics, in press.
[60] Fischer, C., Kuchenbacker, K., Engel, C., Zachariae, S., Rhiem, K., Meindl, A., Rahner, N., Dikow, N., Plendl, H., Debatin, I., Grimm, T., Gadzicki, D., Flottmann, R., Horvath, J., Schrock, E., Stock, F., Schafer, D., Schwaab, I., Kartsonaki, C., Mavaddat, N., Schlegelberger, B., Antoniou, A.C. and Schmutzler, R. (2013) German Consortium for Hereditary Breast and Ovarian Cancer: Evaluating the Performance of the Breast Cancer Genetic Risk Models BOADICEA, IBIS, BRCAPRO and Claus for Predicting BRCA1/2 Mutation Carrier Probabilities: A Study Based on 7352 Families from the German Hereditary Breast and Ovarian Cancer Consortium. Journal of Medical Genetics, 50, 360-367.
[61] MacInnis, R.J., Bickerstaffe, A., Apicella, C., Dite, G.S., Dowty, J.G., Aujard, K., Phillips, K.A., Weideman, P., Lee, A., Terry, M.B., Giles, G.G., Southey, M.C., Antoniou, A.C. and Hopper, J.L. (2013) Prospective Validation of the Breast Cancer Risk Prediction Model BOADICEA and a Batch-Mode Version BOADICEACentre. British Journal of Cancer, 109, 1296-1301.
[62] Long, J., Delahanty, R.J., Li, G.L., Gao, Y.T., Lu, W., Cai, Q.Y., Xiang, Y.B., Li, C., Ji, B.T., Zheng, Y., Ali, S., Shu, X.O. and Zheng, W. (2013) A Common Deletion in the APOBEC3 Genes and Breast Cancer Risk. Journal of the National Cancer Institute, 105, 573-579.
[63] Masson, A.L., Talseth-Palmer, B.A., Evans, T.J., Grice, D.M., Hannan, G.N. and Scott, R.J. (2014) Expanding the Genetic Basis of Copy Number Variation in Familial Breast Cancer. Hereditary Cancer in Clinical Practice, 12, 15.
[64] Krepischi, A.C., Achatz, M.I., Santos, E.M., Costa, S.S., Lisboa, B.C., Brentani, H., Santos, T.M., Goncalves, A., Nóbrega, A.F., Pearson, P.L., Vianna-Morgante, A.M., Carraro, D.M., Brentani, R.R. and Rosenberg, C. (2012) Germline DNA Copy Number Variation in Familial and Early-Onset Breast Cancer. Breast Cancer Research, 14, R24.
[65] Kuusisto, K.M., Akinrinade, O., Vihinen, M., Kankuri-Tammilehto, M., Laasanen, S.L. and Schleutker, J. (2013) Copy Number Variation Analysis in Familial BRCA1/2-Negative Finnish Breast and Ovarian Cancer. PLoS ONE, 8, e71802.
[66] Frank, B., Bermejo, J.L., Hemminki, K., Sutter, C., Wappenschmidt, B., Meindl, A., Kiechle-Bahat, M., Bugert, P., Schmutzler, R.K., Bartram, C.R. and Burwinkel, B. (2007) Copy Number Variant in the Candidate Tumor Suppressor Gene MTUS1 and Familial Breast Cancer Risk. Carcinogenesis, 28, 1442-1445.
[67] Tervasmaki, A., Winqvist, R., Jukkola-Vuorinen, A. and Pylkas, K. (2014) Recurrent CYP2C19 Deletion Allele Is Associated with Triple-Negative Breast Cancer. BMC Cancer, 14, 902.
[68] Ledet, E.M., Hu, X.F., Sartor, O., Rayford, W., Li, M. and Mandal, D. (2013) Characterization of Germline Copy Number Variation in High-Risk African American Families with Prostate Cancer. The Prostate, 73, 614-623.
[69] Liu, W.N., Sun, J.S., Li, G., Zhu, Y., Zhang, S., Kim, S.T., Sun, J.L., Wiklund, F., Wiley, K., Isaacs, S.D., Stattin, P., Xu, J., Duggan, D., Carpten, J.D., Isaacs, W.B., Gronberg, H., Zheng, S.L. and Chang, B.L. (2009) Association of a Germ-Line Copy Number Variation at 2p24.3 and Risk for Aggressive Prostate Cancer. Cancer Research, 69, 2176-2179.
[70] Emeville, E., Broquère, C., Brureau, L., Ferdinand, S., Blanchet, P., Multigner, L. and Romana, M. (2014) Copy Number Variation of GSTT1 and GSTM1 and the Risk of Prostate Cancer in a Caribbean Population of African Descent. PLoS ONE, 9, e107275.
[71] Zhang, X.M., Lin, J., Wu, X.F., Lin, Z.N., Ning, B.T., Kadlubar, S. and Kadlubar, F.F. (2012) Association between GSTM1 Copy Number, Promoter Variants and Susceptibility to Urinary Bladder Cancer. International Journal of Molecular Epidemiology and Genetics, 3, 228-236.
[72] Marenne, G., Real, F.X., Rothman, N., Rodríguez-Santiago, B., Pérez-Jurado, L., Kogevinas, M., García-Closas, M., Silverman, D.T., Chanock, S.J., Génin, E. and Malats, N. (2012) Genome-Wide CNV Analysis Replicates the Association between GSTM1 Deletion and Bladder Cancer: A Support for Using Continuous Measurement from SNP-Array Data. BMC Genomics, 13, 326.
[73] Conde, L., Riby, J., Zhang, J.Q., Bracci, P.M. and Skibola, C.F. (2014) Copy Number Variation Analysis on a Non-Hodgkin Lymphoma Case-Control Study Identifies an 11q25 Duplication Associated with Diffuse Large B-Cell Lymphoma. PLoS ONE, 9, e105382.

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.