Association of Graves’ Disease and Systemic Lupus Erythematosus


Summary of Lupus and Basedow Disease Association: The association lupus auto-immune thyroid disease is well known. Lupus is most commonly associated with Hashimoto’s thyroiditis. As for Graves’ disease, it is most often associated with pernicious anaemia, vitiligo, idiopathic purpura and myasthenia gravis. To our knowledge, we report the first case of lupus associated with Graves’ disease in sub-Saharan Africa. Observation: A female patient of 52 years old has been followed since February 2010 for systemic lupus diagnosed on biological and immunological clinical ACR criteria. There was no skin ailment and kidneys involved. Combined treatment with high-dose corticosteroids early and rapid decrease and hydroxychloroquine was established with good clinical and biological evolution. One year later the patient developed thyrotoxicosis syndrome and vascular goitre without exophthalmos associated with the presence of antibodies anti receptor of TSH leading to the diagnosis of Graves’ disease. The patient has been treated with synthetic anti-thyroid and beta blocker allowing the regression of clinical symptoms and the normalization of thyroid hormones. Since then, the patient had not shown other signs of systemic affection. Conclusion: Systemic diseases are often associated with autoimmune thyreopathies. But association of lupus with Graves’ disease has been rarely described in the literature. One should always watch out for the occurrence of thyroid disease in front of any systemic disease and vice versa.

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Diagne, N. , Pouye, A. , Faye, A. , Djiba, B. and Ndao, A. (2015) Association of Graves’ Disease and Systemic Lupus Erythematosus. Open Journal of Internal Medicine, 5, 1-4. doi: 10.4236/ojim.2015.51001.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Groussin, L. and Bertherat, J. (2007) Pathologie thyroidienne. Revue Francophone des Laboratoires, 2007, 34-36.
[2] Prabhakar, B.S., Batin, R.S. and Smith, T.J. (2003) Current Perspective in the Pathogenis of Graves’ Disease and Ophtalmopathy. Endocrine Reviews, 24, 802-835.
[3] Gaches, F., Delaire, L., Nadalon, S., Loustau Ralli, V. and Vidal, E. (1988) Fréquence des maladies auto immunes chez 218 patients atteints de pathologie thyroidienne auto-immunes. Revue de Médecine Interne, 19, 173-179.
[4] Boelaert, K., Newby, P.R., Simmonds, M., Holder, R.L., Carr-Smith, J.D., Heward, J.M., Manji, N., Alahabadia, A., Armitage, M., Chatterjee, K.V., Lazarus, J.H., Pearce, S.H., Vaidya, B., Gough, S.C. and Franklyn, J.A. (2010) Prevalence and Relative Risk of Other Autoimmune Diseases in Subjects with Autoimmune Thyroid Disease. The American Journal of Medicine, 123, 183.e1-9.
[5] Appenzeller, S., Pallone, A.T., Natalin, R.A. and Costallat, L.T. (2009) Prévalence of thyroid dysfonction in systemic lupus erythematous. Journal of Clinical Rheumatology, 15, 117-119.
[6] Mzabi, A., Ben Ismail, F., Mrad, B., Karmani, M., Toumi, S., Ahiri, H.H. and Laouani Kechrid, C. (2011) Lupus érythémateux systémique et dysthyroidies. Thyroide/Annales d’Endocrinologie, 72, 388.
[7] Toujani, W., Berriche, O., Zantour, B., Alaya, W. and Sfar, M.H. (2011) Association lupus érythémateux systémique et maladie de Basedow. Thyroide/Annales d’Endocrinologie, 72, 395.
[8] Mokhtar, M., Ben Kacimi, N., Hamida, F., Amrandi, A. and Bouafia, M.T. (2013) Basedow et maladies auto immunes: 2 observations rares. Thyroide/Annales d’Endocrinologie, 4, 353.
[9] Baleva, M., Nikolov, R., Manov, E., Stoikou, A., Shaboni, R., Dourmishev, L. and Nikolov, M. (2013) The Coexistence of Systemic Lupus Erythematous and Thyrotoxicosis: The Diagnostic Value of Anti. International Journal of Immuno- pathology and Pharmacology, 26, 217-222.
[10] Baili, L., Rachdi, I., Ben Dhaou, B., Aydi, Z., Boussein, F., Ketari, S. and Rokbani, L. (2011) Association d’un lupus érythémateux systémique et d’une maladie de Basedow. Etiopathogénie croisée ou association fortuite? Thyroide/ Annales d’Endocrinologie, 72, 391.
[11] Brouet, J.C.L. (1998) Auto-immunité: Mécanismes-physiopathologie. Revue Francaise des laboratoires, 302, 49-51.
[12] Meyer, O. (2005) Lupus érythémateux systémique. EMC—Rhumatologie-Orthopédie, 2, 1-32.
[13] Kaguelidou, F., Carel, J.C. and Lager, J. (2005) Grave’s Diseases in Children. Best Practice and Research Clinical Endocrinology and Metabolism, 28, 233-243.
[14] Léger, J. (2010) Pathologie auto-immune thyroidienne. Archives de Pédiatrie, 17, 595-596.

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