A Rare Case of Reparative Granuloma of Nasal Cavity

Jadi Lingaiah^*, Laxminath Ganji, Sailaja Yella, Kranthi Raj Thatikonda

Department of Otorhinolaryngology—Head & Neck Surgery, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, India.

DOI: 10.4236/ijohns.2014.35052                

Abstract

Giant cell reparative granuloma (GCRG) is a rare, benign tumour that mostly involves the maxilla and mandible. It is rare in the nasal cavity and paranasal sinuses. Here we report a case of GCRG of nasal cavity in 24-year-old man who came with unilateral nasal obstruction, epistaxis and proptosis. CT scan showed soft tissue hypodensity lesion of left nasal cavity. Endoscopic surgical excision and biopsy were done. The pathology was consistent with GCRG. There was no recurrence seen on follow-up for 2 years. A short literature review about diagnosis, clinical behavior, radiological findings and treatment of this tumor entity are given.

Keywords

Reparative Granuloma, Giant Cell Tumour, Aneurysmal Bone Cyst

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Jaffe, H.L. (1953) Giant-Cell Reparative Granuloma, Traumatic Bone Cyst, and Fibrous (Fibro-Osseous) Dysplasia of the Jawbones. Oral Surgery, Oral Medicine, Oral Pathology, 6, 159-175. http://dx.doi.org/10.1016/0030-4220(53)90151-0
[2]	Wiatrak, B.J., Gluckman, J.L., Fabian, R.L. and Wesseler, T.A. (1987) Giant Cell Reparative Granuloma of the Ethmoid Sinus. Otolaryngology—Head and Neck Surgery, 97, 504-509.
[3]	Alappat, J.P., Pillai, A.M., Prasanna, D. and Sambasivan, M. (1992) Giant Cell Reparative Granuloma of the Craniofacial Complex: Case Report and Review of the Literature. British Journal of Neurosurgery, 6, 71-74. http://dx.doi.org/10.3109/02688699209002905
[4]	Rogers, L.F., Mikhael, M., Christ, M. and Wolff, A. (1984) Case Report 276. Skeletal Radiology, 12, 48-53. http://dx.doi.org/10.1007/BF00373177
[5]	Oda, Y., Tsuneyoshi, M. and Shinohara, N. (1992) “Solid” Variant of Aneurismal Bone Cyst (Extragnathic Giant Cell Reparative Granuloma) in the Axial Skeleton and Long Bones: A Study of Its Morphologic Spectrum and Distinction from Allied Giant Cell Lesions. Cancer, 70, 2642-2649. http://dx.doi.org/10.1002/1097-0142(19921201)70:11<2642::AID-CNCR2820701113>3.0.CO;2-#
[6]	Ilaslan, H., Sundaram, M. and Unni, K.K. (2003) Solid Variant of Aneurismal Bone Cysts in Long Tubular Bones: Giant Cell Reparative Granuloma. American Journal of Roentgenology, 180, 1681-1687. http://dx.doi.org/10.2214/ajr.180.6.1801681
[7]	Hoopes, P.C., Anderson, R.L. and Blodi, F.C. (1981) Giant Cell (Reparative) Granuloma of the Orbit. Ophthalmology, 88, 1361-1366. http://dx.doi.org/10.1016/S0161-6420(81)34851-9
[8]	Gunel, C., Erpek, G. and Meteoglu, I. (2007) Giant Cell Reparative Granuloma in the Hard Palate. International Journal of Pediatric Otorhinolaryngology Extra, 2, 76-79. http://dx.doi.org/10.1016/j.pedex.2007.02.001
[9]	Kaffe, I., Ardekian, L., Taicher, S., Littner, M.M. and Buchner, A. (1996) Radiologic Features of Central Giant Cell Granuloma of the Jaws. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 81, 720-726. http://dx.doi.org/10.1016/S1079-2104(96)80079-5
[10]	Rhea, J.T. and Weber, A.L. (1983) Giant-Cell Granuloma of the Sinuses. Radiology, 147, 135-137. http://dx.doi.org/10.1148/radiology.147.1.6828718
[11]	Friedberg, S.A., Eisenstein, R. and Wallner, L.J. (1969) Giant Cell Lesions Involving the Nasal Accessory Sinuses. Laryngoscope, 79, 763-776. http://dx.doi.org/10.1288/00005537-196905000-00001
[12]	Lorenzo, J.C. and Dorfman, H.D. (1980) Giant-Cell Reparative Granuloma of Short Tubular Bones of the Hands and Feet. The American Journal of Surgical Pathology, 4, 551-563. http://dx.doi.org/10.1097/00000478-198012000-00006
[13]	Nemoto, Y., Inoue, Y., Tashiro, T., et al. (1995) Central Giant Cell Granuloma of the Temporal Bone. American Journal of Neuroradiology, 16, 982-985.
[14]	Murphey, M.D., Nomikos, G.C., Flemming, D.J., et al. (2001) From the Archives of AFIP: Imaging of Giant Cell Tumor and Giant Cell Reparative Granuloma of Bone: Radiologic-Pathologic Correlation. Radiographics, 21, 1283-1309. http://dx.doi.org/10.1148/radiographics.21.5.g01se251283
[15]	Austin, L.T., Dahlin, D.C. and Royer, R.Q. (1959) Giant Cell Granuloma and Related Conditions Affecting Jaw Bones: An Analysis of 38 Cases. Oral Surgery, Oral Medicine, Oral Pathology, 12, 1285. http://dx.doi.org/10.1016/0030-4220(59)90215-4
[16]	Chuong, R., Kaban, L.B., Kozakewich, H. and Perez-Atayde, A. (1986) Central Giant Cell Lesions of the Jaws: A Clinicopathologic Study. Journal of Oral and Maxillofacial Surgery, 44, 708-713. http://dx.doi.org/10.1016/0278-2391(86)90040-6
[17]	Theologie-Lygidakis, N., Telona, P., Michail-Strantzia, C., et al. (2011) Treatment of Central Giant-Cell Granulomas of the Jaw Inchildren: Conservative or Radical Surgical Approach? Journal of Cranio-Maxillofacial Surgery, 39, 639-644. http://dx.doi.org/10.1016/j.jcms.2010.11.010
[18]	Yoshida, T., Sakamoto, A., Tanaka, K., Matsuda, S., Oda, Y. and Iwamoto, Y. (2007) Alternative Surgical Treatment for Giant-Cell Reparative Granuloma in the Metacarpal, Using Phenol and Ethanol Adjuvant Therapy. Journal of Hand Surgery, 32, 887-892. http://dx.doi.org/10.1016/j.jhsa.2007.04.001