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The Associations for Vaginal Point Doses of Vaginal Stenosis in Image-Guided Brachytherapy

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DOI: 10.4236/jct.2014.59090    2,174 Downloads   2,726 Views  

ABSTRACT

Purpose: To evaluate the associations for vaginal dose points of vaginal stricture in image-guided brachytherapy. Materials and Methods: Twenty-six patients of locally advanced cervical cancer were treated with Image-Guided Brachytherapy (IGBT) with the dose at least 7 Gy per fraction to the D90 of High-Risk Clinical Target Volume (HR-CTV). The vaginal dose points of recommendations of the American Brachytherapy Society (ABS) were added into the plan and cumulative dose to these points was evaluated in Equivalent Dose of 2 Gy (EQD2) concepts. Results: The mean doses to right vaginal dose point (VR), left vaginal dose point (VL) and average dose of VR/VL ((VR + VL)/2) were 101.5 Gy, 98.2 Gy and 99.8 Gy in EQD2 concepts, respectively. Volume-based planning significantly reduced the cumulative dose in EQD2 concepts at vaginal points. At the median follow-up time of 22 months, grade-2 vaginal stricture was observed in two patients. The incidences of vaginal stricture were not differed between the cumulative dose to vaginal dose points in EQD2 concepts of ≤90 Gy versus >90 Gy (P = 1.000) and ≤100 Gy versus >100 Gy (P = 0.815). Conclusion: No association for cumulative vaginal doses and events of vaginal stricture was found.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Tharavichitkul, E. , Jayavasti, R. , Galalae, R. , Tippanya, D. , Prasitwattanaseree, S. , Nobnop, W. , Chakrabandhu, S. , Klunklin, P. , Onchan, W. , Wanwilairat, S. and Chitapanarux, I. (2014) The Associations for Vaginal Point Doses of Vaginal Stenosis in Image-Guided Brachytherapy. Journal of Cancer Therapy, 5, 823-829. doi: 10.4236/jct.2014.59090.

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