Pregnancy and Klippel-Trenaunay Syndrome—A Case Report


Klippel-Trenaunay Syndrome (KTS) is a rare triad of congenital vascular malformations involving extensive Port wine stains, soft tissue or bone hypertrophy and underlying venous and/or lymphatic malformation affecting limb, pelvicor abdominal organs. Pregnancy is known to exacerbate KTS complications and can put women at increased obstetrical risk due to deep venous thrombosis and other thromboembolic events. We report a case of a pregnant woman with KTS with the personal antecedent of two episodes of pulmonary thromboembolism.

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Hidalgo, M. , Segura, G. , Lisbona, L. and García, E. (2014) Pregnancy and Klippel-Trenaunay Syndrome—A Case Report. Case Reports in Clinical Medicine, 3, 429-432. doi: 10.4236/crcm.2014.37095.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Sreekar, H., Dawre, S., Petkar, K.S., Shetty, R.B., Lamba, S., Naik, S. and Gupta, A.K. (2013) Diverse Manifestations and Management Options in Klippel-Trenaunay Syndrome: A Single Centre 10-Year Experience. Journal of Plastic Surgery and Hand Surgery, 47, 303-307.
[2] Hofer, T., Frank, J. and Itin, P.H. (2005) Klippel-Trenaunay Syndrome in a Monozygotic Male Twin: Supportive Evidence for the Concept of Paradominant Inheritance. European Journal of Dermatology, 15, 341-343.
[3] Herman, R., Kunisaki, S., Molitor, M., Gadepalli, S., Dillman, J.R. and Geiger, J. (2012) Rectal Bleeding, Deep Venous Thrombosis, and Coagulopathy in a Patient with Klippel-Trénaunay Syndrome. Journal of Pediatric Surgery, 47, 598-600.
[4] Barbara, D.W. and Wilson, J.L. (2011) Anesthesia for Surgery Related to Klippel-Trenaunay Syndrome: A Review of 136 Anesthetics. Anesthesia Analgesia, 113, 98-102.
[5] Klippel, M. and Trenaunay, P. (1900) Naevus Variquenx Osteohypertophique. Archives Générales de Médecine, 3, 641-672.
[6] Ziyeh, S., Spreer, J., Rössler, J., Strecker, R., Hochmuth, A., Schumacher, M. and Klisch, J. (2004) Parkes Weber or Klippel-Trenaunay Syndrome? Non-Invasive Diagnosis with MR Projection Angiography. European Radiology, 14, 2025-2029.
[7] Gloviczki, P. and Driscoll, D.J. (2007) Klippel-Trenaunay Syndrome: Current Management. Phlebology, 22, 291-298.
[8] Blasco, M. and Herrera, J. (2012) Klippel-Trenaunay Syndrome Complicating Pregnancy. BMJ Case Reports.
[9] Stein, S.R., Perlow, J.H. and Sawai, S.K. (2006) Klippel-Trenaunay-Type Syndrome in Pregnancy. Obstetrical Gynecological Survey, 61, 194-206.
[10] Torres-Farías, E., Torres-Gómez, L.G. and Burciaga-Sepúlveda, A.S. (2010) Klippel-Trenaunay Syndrome and Pregnancy. Case Report. Ginecologíay Obstetetricia de Mexico, 78, 287-290.
[11] Redondo, P., Aguado, L. and Martínez-Cuesta, A. (2011) Diagnosis and Management of Extensive Vascular Malformations of the Lower Limb: Part II. Systemic Repercussions, Diagnosis, and Treatment. Journal of the American Academy of Dermatology, 65, 909-923.
[12] Peng, H.H., Wang, T.H., Chao, A.S., Chang, Y.L., Shieh, S.C. and Chang, S.D. (2006) Klippel-Trenaunay-Weber Syndrome Involving Fetal Thigh: Prenatal Presentations and Outcomes. Prenatal Diagnosis, 26, 825-830.
[13] Chen, C.P., Lin, S.P., Chang, T.Y., Lee, H.C., Hung, H.Y., Lin, H.Y., Huang, J.P. and Wang, W. (2007) Prenatal Sonographic Findings of Klippel-Trénaunay-Weber Syndrome. Journal of Clinical Ultrasound, 35, 409-412.
[14] Fait, G., Daniel, Y., Kupferminc, M.J., Gull, I., Peyser, M.R. and Lessing, J.B. (1996) Klippel-Trénaunay-Weber Syndrome Associated with Fetal Growth Restriction. Human Reproduction, 11, 2544-2545.
[15] Güngor Gündogan, T. and Jacquemyn, Y. (2010) Klippel-Trenaunay Syndrome and Pregnancy. Obstetrics and Gynecology International, 2010, Article ID: 706850.
[16] Lee, J.H., Chung, H.U. and Lee, M.S. (2012) An Anesthetic Management of a Patient with Klippel-Trenaunay Syndrome. Korean Journal of Anesthesiology, 63, 90-91.

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