Kimura’s Disease—A Rare Cause of Head and Neck Swelling

DOI: 10.4236/ijohns.2014.34037   PDF   HTML   XML   3,902 Downloads   5,561 Views   Citations

Abstract

Kimura’s disease (KD) is a chronic inflammatory disorder with unknown etiology, most commonly manifesting as painless unilateral cervical lymphadenopathy or subcutaneous masses in the head or neck region. The disease is characterized by a triad of painless subcutaneous masses in the head or neck region, blood and tissue eosinophilia, and markedly elevated serum immunoglobulin E levels. Kimura’s disease is an unusual vascular tumor that typically occurs at 20 to 30 years of age. There has been no documented case of malignant transformation; however, recurrence rates after excision may be as high as 25%. Surgery and medical therapy are useful for treatment. We present a 14 years old male developed a unilateral cervical mass associated with KD. It was a recurrence of disease. As a complete excisional resection of the mass already done 1 year back at some other centre, we decided to give medical treatment for Kimura’s disease.

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Rao, K. and Kumar, S. (2014) Kimura’s Disease—A Rare Cause of Head and Neck Swelling. International Journal of Otolaryngology and Head & Neck Surgery, 3, 200-204. doi: 10.4236/ijohns.2014.34037.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Lee, S. (2007) Kimura Disease. eMedicine. http://www.emedicine.com/derm/topic212.htm
[2] Kimm, H.T. and Szeto, C. (1937) Eosinophilic Hyperplastic Lymphogranuloma, Comparison with Mikulicz’s Disease. Proc Chin Med Soc, 329.
[3] Kimura, T., Yoshimura, S. and Ishikawa, E. (1948) On the Unusual Granulation Combined with Hyperplastic Changes of Lymphatic Tissues. Trans Soc Pathol Jpn, 37, 179-180.
[4] Ben-Chetrit, E., Amir, G. and Shalit, M. (2005) Cetirizine: An Effective Agent in Kimura’s Disease. Arthritis & Rheumatology, 53, 117-118.
http://dx.doi.org/10.1002/art.20908
[5] http://emedicine.medscape.com/article/1098777-treatment
[6] Ramchandani, P.L., Sabesan, T. and Hussein, K. (2005) Angiolymphoid Hyperplasia with Eosinophilia Masquerading as Kimura Disease. British Journal of Oral and Maxillofacial Surgery, 43, 249-252.
http://dx.doi.org/10.1016/j.bjoms.2004.11.023
[7] Ohta, N., Fukase, S., Suzuki, Y., Ito, T., Yoshitake, H. and Aoyagi, M. (2011) Increase of Th2 and Tc1 Cells in Patients with Kimura’s Disease. Auris Nasus Larynx, 38, 77-82.
http://dx.doi.org/10.1016/j.anl.2010.03.011
[8] Katagiri, K., Itami, S., Hatano, Y., Yamaguchi, T. and Takayasu, S. (1997) In Vivo Expression of IL-4, IL-5, IL-13 and IFN-Gamma mRNAs in Peripheral Blood Mononuclear Cells and Effect of Cyclosporin A in a Patient with Kimura’s Disease. British Journal of Dermatology, 137, 972-977.
http://dx.doi.org/10.1111/j.1365-2133.1997.tb01562.x
[9] Sun, Q.F., Xu, D.Z., Pan, S.H., et al. (2008) Kimura Disease: Review of the Literature. Internal Medicine Journal, 38, 668-672.
http://dx.doi.org/10.1111/j.1445-5994.2008.01711.x
[10] Wang, D.Y., Mao, J.H., Zhang, Y., et al. (2009) Kimura Disease: A Case Report and Review of the Chinese Literature. Nephron Clinical Practice, 111, c55-c61.
http://dx.doi.org/10.1159/000178980
[11] Kung, I.T., Gibson, J.B. and Bannatyne, P.M. (1984) Kimura’s Disease: A Clinico-Pathological Study of 21 Cases and Its Distinction from Angiolymphoid Hyperplasia with Eosinophilia. Pathology, 16, 39-44.
http://dx.doi.org/10.3109/00313028409067909
[12] Thomas, J., Jayachandran, N.V., Chandrasekhara, P.K., Rajasekhar, L. and Narsimulu, G. (2008) Kimura’s Disease—An Unusual Cause of Lymphadenopathy in Children. Clinical Rheumatology, 27, 675-677.
http://dx.doi.org/10.1007/s10067-007-0821-9
[13] Chen, H., Thompson, L.D., Aguilera, N.S. and Abbondanzo, S.L. (2004) Kimura Disease: A Clinicopathologic Study of 21 Cases. The American Journal of Surgical Pathology, 28, 505-513.
http://dx.doi.org/10.1097/00000478-200404000-00010
[14] Rajpoot, D.K., Pahl, M. and Clark, J. (2000) Nephrotic Syndrome Associated with Kimura Disease. Pediatric Nephrology, 14, 486-488.
http://dx.doi.org/10.1007/s004670050799
[15] Yoganathan, P., Meyer, D.R. and Farber, M.G. (2004) Bilateral Lacrimal Gland Involvement with Kimura Disease in an African American Male. Archives of Ophthalmology, 122, 917-919.
[16] Park, S.W., Kim, H.J., Sung, K.J., Lee, J.H. and Park, I.S. (2012) Kimura Disease: CT and MR Imaging Findings. American Journal of Neuroradiology, 33, 784-788.
[17] Kaneko, K., Aoki, M., Hattori, S., Sato, M. and Kawana, S. (1999) Successful Treatment of Kimura’s Disease with Cyclosporine. Journal of the American Academy of Dermatology, 41, 893-894.
http://dx.doi.org/10.1016/S0190-9622(99)70354-3
[18] Hernandez-Bautista, V., Yamazaki-Nakashimada, M.A., Vazquez-Garcia, R., Stamatelos-Albarran, D., Carrasco-Daza, D. and Rodriguez-Lozano, A.L. (2011) Treatment of Kimura Disease with Intravenous Immunoglobulin. Pediatrics, 128, e1633-e1635.
[19] Hongcharu, W., Baldassano, M. and Taylor, C.R. (2000) Kimura’s Disease with Oral Ulcers: Response to Pentoxifylline. Journal of the American Academy of Dermatology, 43, 905-907.
http://dx.doi.org/10.1067/mjd.2000.101931
[20] Hareyama, M., Oouchi, A., Nagakura, H., et al. (1998) Radiotherapy for Kimura’s Disease: The Optimum Dosage. International Journal of Radiation Oncology * Biology * Physics, 40, 647-651.
http://dx.doi.org/10.1016/S0360-3016(97)00813-4

  
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