Patterns of Medication Use among Romanian Nursing Home Residents

Abstract

Background: the elderly are frequently exposed to drug-related problems and their consequences. Information relating to the appropriateness of the medication used by Romanian elderly is scarce. Objective: to identify the main potential inappropriate prescribing (PIP) instances in a sample of Romanian elderly nursing-home residents, concerning prevalence and subtypes. Methodology: the residents’ medical data were reviewed by a clinical pharmacist considering published geriatric pharmacotherapy recommendations, including four published PIP evaluation tools (the Beers criteria, STOPP-START tools, the PRISCUS list). Results: 91 residents were evaluated; mean age (mean ± SD) was 80.77 ± 6.82 (years), 28 (31%) were ≥85 years old and 58 (64%) had dementia. The median number of diagnoses was 6 (range 2 - 11) and the mean number (±SD) of daily medications was 8.26 (±3.52). An estimated mean (±SD) of 2 (±1.41) PIP per resident was identified, with 117 misuse-PIP (46.24%), 60 underuse-PIP (23.72%), 41 lack of monitoring-PIP (16.21%) and 35 overuse-PIP (13.83%). The most frequent PIP subtypes were the use of nonsteroidal anti-inflammatory drugs as chronic analgesic treatment in osteoarthritis (29.67%), underuse of fall prevention (100%) and analgesic therapies (23.08%), overuse of nootropic medications (26.98%) and lack of annual creatinine assessment (30.77%). Conclusion: a more geriatric-oriented care seemed to be necessary, but larger studies are needed to confirm these findings.

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Primejdie, D. , Bojita, M. , Revnic, C. and Popa, A. (2014) Patterns of Medication Use among Romanian Nursing Home Residents. Pharmacology & Pharmacy, 5, 560-569. doi: 10.4236/pp.2014.56066.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Guaraldo, L., Cano, F.G., Damasceno, G.S. and Rozenfeld, S. (2011) Inappropriate Medication Use among the Elderly: A Systematic Review of Administrative Databases. BMC Geriatrics, 11, 79.
http://dx.doi.org/10.1186/1471-2318-11-79
[2] O’Mahony, D. and Gallagher, P.F. (2008) Inappropriate Prescribing in the Older Population: Need for New Criteria. Age Ageing, 37, 138-141.
http://dx.doi.org/10.1093/ageing/afm189
[3] Fick, D.M., Cooper, J.W., Wade, W.E., Waller, J.L., Maclean, J.R. and Beers, M.H. (2003) Updating the Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. Results of a US Consensus Panel of Experts. Archives of Internal Medecine, 163, 2716-2724.
http://dx.doi.org/10.1001/archinte.163.22.2716
[4] Spinewine, A., Schmader, K.E., Barber, N., Hughes, C., Lapane, K.L., Swine, C., et al. (2007) Appropriate Prescribing in Elderly People: How Well Can It Be Measured and Optimised? Lancet, 370, 173-184.
http://dx.doi.org/10.1016/S0140-6736(07)61091-5
[5] Gallagher, P., Ryan, C., Byrne, S., Kennedy, J. and O’Mahony, D. (2008) STOPP (Screening Tool of Older Person’s Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus Validation. InternationalJournal of Clinical Pharmacology and Therapeutics, 46, 72-83.
http://dx.doi.org/10.5414/CPP46072
[6] The American Geriatrics Society 2012 Beers Criteria Update Expert Panel (2012) American Geriatrics Society Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. Journal of American Geriatrics Society, 60, 616-631.
http://dx.doi.org/10.1111/j.1532-5415.2012.03923.x
[7] Holt, S., Schmiedl, S. and Thürmann, P.A. (2010) Potentially Inappropriate Medications in the Elderly: The PRISCUS List. Deutsches Ärzteblatt International, 107, 543-551.
http://dx.doi.org/10.3238/arztebl.2010.0543
[8] Ruggiero, C., Dell’Aquila, G., Gasperini, B., Onder, G., Lattanzio, F., Volpato, S., et al. (2010) Potentially Inappropriate Drug Potentially Inappropriate Drug Prescriptions and Risk of Hospitalization among Older, Italian, Nursing Home Residents: The ULISSE Project. Drugs Aging, 27, 747-758.
http://dx.doi.org/10.2165/11538240-000000000-00000
[9] Lund, B.C., Carnahan, R.M., Egge, J.A., Chrischilles, E.A. and Kaboli, P.J. (2010) Inappropriate Prescribing Predicts Adverse Drug Events in Older Adults. Annals of Pharmacotherapy, 44, 957-963.
http://dx.doi.org/10.1345/aph.1M657
[10] Dedhiya, S.D., Hancock, E., Craig, B.A., Doebbeling, C.C. and Thomas 3rd, J. (2010) Incident Use and Outcomes Associated with Potentially Inappropriate Medication Use in Older Adults. American Journal of Geriatric Pharmacotherapy, 8, 562-570.
http://dx.doi.org/10.1016/S1543-5946(10)80005-4
[11] The 2011 Population and Housing Census (2013) The National Institute of Statistics.
http://www.recensamantromania.ro/rezultate-2/
[12] Pop, M.A., Matei, A. and Garoschy, D. (2013) Public Health System Reform 2012. The National Council for the elderly.
http://www.cnpv.ro/pdf/analize2012/Reforma%20sistemului%20public%20de%20sanatate.pdf
[13] Law No. 17/2000 Referring to Social Care of the Elderly (Republished) (2007) Official Journal of Romania 1st Part, No. 157.
http://www.dreptonline.ro/legislatie/legea_asistenta_persoane_varstnice.php.
[14] Fialová, D., Topinková, E., Gambassi, G., Finne-Soveri, H., Jónsson, P.V., Carpenter, I., et al. (2005) Potentially Inappropriate Medication Use among Elderly Home Care Patients in Europe. JAMA, 293, 1348-1358.
http://dx.doi.org/10.1001/jama.293.11.1348
[15] Spinewine, A., Fialová, D. and Byrne, S. (2012) The Role of the Pharmacist in Optimizing Pharmacotherapy in Older People. Drugs Aging, 29, 495-510.
http://dx.doi.org/10.2165/11631720-000000000-00000
[16] American Geriatrics Society Panel on the Pharmacological Management of Persistent Pain in Older Persons (2009) Pharmacological Management of Persistent Pain in Older Persons. Journal of the American Geriatrics Society, 57, 1331-1346.
http://dx.doi.org/10.1111/j.1532-5415.2009.02376.x
[17] Phoon, R.K. (2012) Chronic Kidney Disease in the Elderly—Assessment and Management. Australian Family Physician, 41, 940-944.
[18] WHO Collaborating Centre for Drug Statistics Methodology (2013) Guidelines for ATC Classification and DDD Assignment 2013.
http://www.whocc.no/filearchive/publications/1_2013guidelines.pdf
[19] Parsons, C., Johnston, S., Mathie, E., Baron, N., Machen, I., Amador, S., et al. (2012) Potentially Inappropriate Prescribing in Older People with Dementia in Care Homes: A Retrospective Analysis. Drugs & Aging, 29, 143-155.
http://dx.doi.org/10.2165/11598560-000000000-00000
[20] Chen, L.L., Tangiisuran, B., Shafie, A.A. and Hassali, M.A. (2012) Evaluation of Potentially Inappropriate Medications among Older Residents of Malaysian Nursing Homes. International Journal of Clinical Pharmacy, 34, 596-603.
http://dx.doi.org/10.1007/s11096-012-9651-1
[21] Olsson, J., Bergman, A., Carlsten, A., Oké, T., Bernsten, C., Schmidt, I.K., et al. (2010) Quality of Drug Prescribing in Elderly People in Nursing Homes and Special Care Units for Dementia: A Cross-Sectional Computerized Pharmacy Register Analysis. Clinical Drug Investigation, 30, 289-300.
http://dx.doi.org/10.2165/11534320-000000000-00000
[22] Shah, S.M., Carey, I.M., Harris, T., DeWilde, S. and Cook, D.G. (2012) Quality of Prescribing in Care Homes and the Community in England and Wales. British Journal of General Practice, 62, e329-e336.
http://dx.doi.org/10.3399/bjgp12X641447
[23] Stafford, A.C., Alswayan, M.S. and Tenni, P.C. (2011) Inappropriate Prescribing in Older Residents of Australian Care Homes. Journal of Clinical Pharmacy and Therapeutics, 36, 33-44.
http://dx.doi.org/10.1111/j.1365-2710.2009.01151.x
[24] Hansen, R.A., Greene, S.B., Williams, C.E., Blalock, S.J., Crook, K.D., Akers, R., et al. (2006) Types of Medication Errors in North Carolina Nursing Homes: A Target for Quality Improvement. The American Journal of Geriatric Pharmacotherapy, 4, 52-61.
http://dx.doi.org/10.1016/j.amjopharm.2006.03.007
[25] Wawruch, M., Fialova, D., Zikavska, M., Wsolova, L., Jezova, D., Kuzelova, M., et al. (2008) Factors Influencing the Use of Potentially Inappropriate Medication in Older Patients in Slovakia. Journal of Clinical Pharmacy and Therapeutics, 33, 381-392.
http://dx.doi.org/10.1111/j.1365-2710.2008.00929.x
[26] Feng, Z., Hirdes, J.P., Smith, T.F., Finne-Soveri, H., Chi, I., Du Pasquier, J.N., et al. (2009) Use of Physical Restraints and Antipsychotic Medications in Nursing Homes: A Cross-National Study. International Journal of Geriatric Psychiatry, 24, 1110-1118.
http://dx.doi.org/10.1002/gps.2232
[27] Azermai, M., Elseviers, M., Petrovic, M., van Bortel, L. and Stichele, R.V. (2011) Assessment of Antipsychotic Prescribing in Belgian Nursing Homes. International Psychogeriatrics, 23, 1240-1248.
http://dx.doi.org/10.1017/S104161021100024X
[28] Seitz, D.P., Gill, S.S. and Van Zyl, L.T. (2007) Antipsychotics in the Treatment of Delirium: A Systematic Review. Journal of Clinical Psychiatry, 68, 11-21.
http://dx.doi.org/10.4088/JCP.v68n0102
[29] Mann, E., Köpke, S., Haastert, B., Pitkälä, K. and Meyer, G. (2009) Psychotropic Medication Use among Nursing Home Residents in Austria: A Cross-Sectional Study. BMC Geriatrics, 9, 18.
http://dx.doi.org/10.1186/1471-2318-9-18.
[30] Bourgeois, J., Elseviers, M.M., Azermai, M., Van Bortel, L., Petrovic, M. and Stichele, R.R.V. (2012) Benzodiazepine Use in Belgian Nursing Homes: A Closer Look into Indications and Dosages. European Journal of Clinical Pharmacology, 68, 833-844.
http://dx.doi.org/10.1007/s00228-011-1188-z
[31] Barreto, P.S., Lapeyre-Mestre, M., Mathieu, C., Piau, C., Bouget, C., Cayla, F., et al. (2013) Indicators of Benzodiazepine Use in Nursing Home Residents in France: A Cross-Sectional Study. Journal of the American Medical Directors Association, 14, 29-33.
http://dx.doi.org/10.1016/j.jamda.2012.09.002
[32] Rudolph, J.L., Salow, M.J., Angelini, M.C. and McGlinchey, R.E. (2008) The Anticholinergic Risk Scale and Anticholinergic Adverse Effects in Older Persons. Archives of Internal Medicine, 168, 508-513.
http://dx.doi.org/10.1001/archinternmed.2007.106
[33] Chatterjee, S., Mehta, S., Sherer, J.T. and Aparasu, R.R. (2010) Prevalence and Predictors of Anticholinergic Medication Use in Elderly Nursing Home Residents with Dementia Analysis of Data from the 2004 National Nursing Home Survey. Drugs Aging, 27, 987-997.
http://dx.doi.org/10.2165/11584430-000000000
[34] Won, A.B., Lapane, K.L., Vallow, S., Schein, J., Morris, J.N. and Lipsitz, L.A. (2004) Persistent Nonmalignant Pain and Analgesic Prescribing Patterns in Elderly Nursing Home Residents. Journal of the American Geriatric Society, 52, 867-874.
http://dx.doi.org/10.1111/j.1532-5415.2004.52251.x
[35] Jablonski, A. and Ersek, M. (2009) Nursing Home Staff Adherence to Evidence-Based Pain Management Practices. Journal of Gerontological Nursing, 35, 28-34.
http://dx.doi.org/10.3928/00989134-20090701-02
[36] Takai, Y., Yamamoto-Mitani, N., Okamoto, Y., Koyama, K. and Honda, A. (2010) Literature Review of Pain Prevalence among Older Residents of Nursing Homes. Pain Management Nursing, 11, 209-223.
http://dx.doi.org/10.1016/j.pmn.2010.08.006
[37] Lukas, A., Mayer, B., Fialová, D., Topinkova, E., Gindin, J., Onder, G., et al. (2013) Pain Characteristics and Pain Control in European Nursing Homes: Cross-Sectional and Longitudinal Results from the Services and Health for Elderly in Long TERm Care (SHELTER) Study. Journal of the American Medical Directors Association, 14, 421-428.
http://dx.doi.org/10.1016/j.jamda.2012.12.010
[38] Wetzels, R.B., Zuidema, S.U., de Jonghe, J.F.M., Verhey, F.R.J. and Koopmans, R.T.C.M. (2011) Prescribing Pattern of Psychotropic Drugs in Nursing Home Residents with Dementia. International Psychogeriatrics, 23, 1249-1259.
http://dx.doi.org/10.1017/S1041610211000755
[39] Bond, M., Rogers, G., Peters, J., Anderson, R., Hoyle, M., Miners, A., et al. (2012) The Effectiveness and Cost-Effectiveness of Donepezil, Galantamine, Rivastigmine and Memantine for the Treatment of Alzheimer’s Disease (Review of Technology Appraisal No. 111): A Systematic Review and Economic Model. Health Technology Assessment, 16, 1-470.
[40] Onder, G., Liperoti, R., Fialova, D., Topinkova, E., Tosato, M., Danese, P., et al. (2012) Polypharmacy in Nursing Home in Europe: Results from the SHELTER Study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 67A, 698-704.
http://dx.doi.org/10.1093/gerona/glr233
[41] Tjia, J., Velten, S.J., Parsons, C., Valluri, S. and Briesacher, B.A. (2013) Studies to Reduce Unnecessary Medication Use in Frail Older Adults: A Systematic Review. Drugs & Aging, 30, 285-307.
http://dx.doi.org/10.1007/s40266-013-0064-1
[42] Mitchell, S.L., Miller, S.C., Teno, J.M., Davis, R.B. and Shaffer, M.L. (2010) The Advanced Dementia Prognostic Tool (ADEPT): A Risk Score to Estimate Survival in Nursing Home Residents with Advanced Dementia. Journal of Pain and Symptom Management, 40, 639-651.
http://dx.doi.org/10.1016/j.jpainsymman.2010.02.014
[43] Marcum, Z.A., Handler, S.M., Wright, R. and Hanlon, J.T. (2010) Interventions to Improve Suboptimal Prescribing in Nursing Homes: A Narrative Review. The American Journal of Geriatric Pharmacotherapy, 8, 183-200.
http://dx.doi.org/10.1016/j.amjopharm.2010.05.004
[44] Alldred, D.P., Raynor, D.K., Hughes, C., Barber, N., Chen, T.F. and Spoor, P. (2013) Interventions to Optimise Prescribing for Older People in Care Homes. Cochrane Database of Systematic Reviews, Article ID: CD009095.
http://dx.doi.org/10.1002/14651858.CD009095.pub2
[45] Khalil, H. (2011) A Review of Pharmacist Recommendations in an Aged Care Facility. Australian Journal of Primary Health, 17, 35-39.
http://dx.doi.org/10.1071/PY10044
[46] Locca, J.F., Ruggli, M., Buchmann, M., Huguenin, J. and Bugnon, O. (2009) Development of Pharmaceutical Care Services in Nursing Homes: Practice and Research in a Swiss Canton. Pharmacy World & Science, 31, 165-173.
http://dx.doi.org/10.1007/s11096-008-9273-9

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