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Melatonin in Pain Modulation: Analgesic or Proalgesic?

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DOI: 10.4236/pst.2014.22009    3,723 Downloads   5,163 Views   Citations

ABSTRACT

Melatonin, as an endogenous hormone produced mainly in the pineal gland in a clear circadian fashion, has diverse physiological functions, such as the control of circadian rhythms, sleep regulation, antioxidant, etc. Recently, accumulating researches about melatonin and pain have been reported. In this review, comparison and summary about analgesic/proalgesic effect of melatonin in inflammatory and neuropathic pain will be made. Some possible pathways of melatonin involved in dual pain modulation might help to explain all these conflicting results in various situations.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Liu, Y. , He, H. and Huang, F. (2014) Melatonin in Pain Modulation: Analgesic or Proalgesic?. Pain Studies and Treatment, 2, 50-55. doi: 10.4236/pst.2014.22009.

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