Case Report on Acute Psychosis Due to Anti-NMDAR Encephalitis


A 32-year-old female with depression on treatment, was presented with acute psychosis, behavioural symptoms, autonomic instability and a prodromal illness. This occurred on a background of a strong family history of schizophrenia. Despite escalating doses of anti-psychotics, she failed to improve. Her CSF showed a lymphocytic pleocytosis and confirmed the presence of anti-NMDAR antibodies. Following treatment with immunotherapy and excision of her underlying ovarian tumour, she showed a dramatic and seemingly full recovery of her psychotic symptoms. She was weaned off all medications with no residual symptoms. Clinician awareness is important to treat this uncommon but potentially reversible condition.

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Ahamed, S. and Karunajeewa, H. (2014) Case Report on Acute Psychosis Due to Anti-NMDAR Encephalitis. Open Journal of Internal Medicine, 4, 28-32. doi: 10.4236/ojim.2014.41005.

Conflicts of Interest

The authors declare no conflicts of interest.


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