CUF, a herbal formula for the treatment of asthma: A randomized, double-blind, placebo-controlled study in the treatment of childhood asthma

Abstract

Background: Complementary and alternative medicines are increasingly used for the treatment of asthma worldwide. A five-herb herbal formula (CUF) has been found to be effective and safe in an animal model of asthma and in a preliminary clinical study. Objective: The objective of this study was to evaluate the safety and efficacy of CUF in children suffering from asthma. Design: A randomized, double blind, and placebo-controlled, parallel study. Interventions: Subjects received CUF or placebo for 6 months. Efficacy variables included changes in forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), Paediatric Asthma Quality of Life Questionnaire (PAQLQ), and steroidal consumption. Results: A total of 100 asthmatic children were enrolled and assigned to two treatment groups. The first group received CUF 6 capsules (3 g/day) and the second group received placebo. There was a statistically significant difference in mean spirometric indexes in CUF group at baseline and follow-up visits. In the CUF group, the activity domain showed significant improvement (p = 0.045). FEV% was significantly improved in the CUF group (p < 0.05) compared with the Placebo group. FEV1 also showed significant improvement after eight weeks of treatment. The requirement for steroids decreased after treatment in both groups, and no significant difference was noted between the two study groups. Conclusion: A beneficial role for CUF therapy in pediatric asthma is demonstrated. It improved the pulmonary functions of the children, namely, FEV1 and FVC. However, further research on a larger scale is warranted.

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Wong, E. , Sung, R. , Leung, P. and Cheng, K. (2013) CUF, a herbal formula for the treatment of asthma: A randomized, double-blind, placebo-controlled study in the treatment of childhood asthma. Health, 5, 1580-1589. doi: 10.4236/health.2013.510214.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Murphy, S., Bleecker, E.R., Boushey, H., et al. (1997) Expert panel report II. Guidelines for the diagnosis and management of asthma. National Institute of Health Publication, National Asthma Education and Prevention Program, Bethesda.
[2] Sears, M.R. (1988) Epidemiology. In: Barnes, P.J., Rodger, I.W. and Thomson, N.C., Eds., Asthma. Basic Mechanisms and Clinical Management, 3rd Edition, Academic Press, San Diego, 1-33.
[3] Gary, W.K. (2005) Wong asthma epidemiology in Chinese: What have we learnt so far? Medical Bulletin, 10, 14-16.
[4] Okelo, S.O., Wu, A.W., Krishnan, J.A., Rand, C.S., Skinner, E.A. and Diette, G.B. (2004) Emotional quality-of-life and outcomes in adolescents with asthma. Journal of Pediatrics, 145, 523-529. http://dx.doi.org/10.1016/j.jpeds.2004.06.043
[5] Goeman, D.P., Aroni, R.A., Stewart, K., et al. (2002) Patients views of the burden of asthma: a qualitative study. Medical Journal of Australia, 177, 295-299.
[6] Gustafsson, D., Olofsson, N., Andersson, F., Lindberg, B. and Schollin, J. (2002) Effect of asthma in childhood on psychosocial problems in the family. Journal of Psychosomatic Research, 53, 1071-1075. http://dx.doi.org/10.1016/S0022-3999(02)00340-9
[7] Osman, L.M., Baxter-Jones, A.D.G. and Helms, P.J. (2001) Parents quality of life and respiratory symptoms in young children with mild wheeze. European Respiratory Journal, 17, 254-258. http://dx.doi.org/10.1183/09031936.01.17202540
[8] Juniper, E.F., Guyatt, G.H., Epstein, R.S., Ferrie, P.J., Jaeschke, R. and Hiller, T.K. (1992) Evaluation of impairment of health related quality of life in asthma: Development of a questionnaire for use in clinical trials. Thorax, 47, 76-83.
http://dx.doi.org/10.1136/thx.47.2.76
[9] Juniper, E.F., Guyatt, G.H., Feeny, D.H., Ferrie, P.J., Griffith, L.E. and Townsend, M. (1996) Measuring quality of life in children with asthma. Quality of Life Research, 5, 35-46. http://dx.doi.org/10.1007/BF00435967
[10] Zhang, J. and Guo, L.-F. (2008) Understanding and thinking about the topical treatment of asthma in children. Journal of Pediatrics of TCM, 3, 6-8.
[11] Lee, S.K.W., Wong, C.K., Sung, R.Y.T., et al. (2006) In vitro anti-allergic activities of a newly concocted traditional Chinese medicine: The wheeze-relief formula. Journal of Ethnopharmacology, 103, 406-412. http://dx.doi.org/10.1016/j.jep.2005.08.031
[12] Sung, R., Wong, Y., Chan, W., et al. (2005) Lung inflammation, goblet cell hyperplasia, cytokine and chemokine production are reduced by a Chinese herbal formulation in a rat model of asthma. Journal of Allergy and Clinical Immunology, 119, S10. http://dx.doi.org/10.1016/j.jaci.2004.12.053
[13] Wong, Y., Sung, R., Li, K., et al. (2006) The Chinese herbal formula CUF2 modulates Th1=Th2 responses in a rat model of allergic asthma. Journal of Allergy and Clinical Immunology, 117, 277. http://dx.doi.org/10.1016/j.jaci.2005.12.1147
[14] Wong, Y., Sung, R., Li, K., et al. (2007) Effects of the Chinese herbal formula CUF2 on cytokine release from human mast cell line. Journal of Allergy and Clinical Immunology, 119, 213. http://dx.doi.org/10.1016/j.jaci.2006.12.203
[15] Beydon, N., Pin, I., Matran, R. and Chaussain, M. (2003) Pulmonary function tests in preschool children with asthma. A American Journal of Respiratory and Critical Care Medicine, 168, 640-670. http://dx.doi.org/10.1164/rccm.200303-449OC
[16] Global Initiative for Asthma (2002) Global strategy for asthma management and prevention. NHLB=WHO Workshop Report. National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda.
[17] Juniper, E.F., Guyatt, G.H., Feeny, D.H., Ferrie, P.J., Grith, L.E. and Townsend, M. (1996) Measuring quality of life in children with asthma. Quality of Life Research, 5, 35-46. http://dx.doi.org/10.1007/BF00435967
[18] Sanjuas, C., Alonso, J., Ferrer, M., Curull, V., Broquetas, J.M. and Anto, J.M. (2001) Adaptation of the asthma quality of life questionnaire to a second language preserves its critical properties: The Spanish version. Journal of Clinical Epidemiology, 54, 182-189, http://dx.doi.org/10.1016/S0895-4356(00)00297-3
[19] Elizabeth, C., Suzanna, S., Tim, C.F., Chi, S.L., Mital, R. and Bee-Wah, L. (1999) Pediatric asthma quality of life questionnaire: Validation in children from Singapore. Asian Pacific Journal of Allergy and Immunology, 17, 155-161.
[20] Pljaskic-Kamenov, S.S., Djordjevic, D.V., Radic, S.S. and Kamenov, B.A. (2002) Asthma quality of life as a marker of disease severity and treatment evaluation in school children. Medicine and Biology, 9, 175-180.
[21] Li, X.M. (2007) Traditional Chinese herbal remedies for asthma and food allergy. Journal of Allergy and Clinical Immunology, 120, 25-31. http://dx.doi.org/10.1016/j.jaci.2007.04.030
[22] Ernst E. (1998) Use of unconventional therapies in childhood asthma. Pediatric Allergy and Immunology, 12, 29-32. http://dx.doi.org/10.1089/pai.1998.12.29
[23] Tam, K. (1998) Theory of Chinese medicine. Cheng Chung Book Co., Taipei.

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