Rose Hip Powder That Contains the Natural Amount of Shells and Seeds Alleviates Pain in Osteoarthritis of the Dominant Hand—A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Clinical Trial


Aim: A standardized preparation of seeds and shells of selected sub-species of Rosa canina L, trade name Hyben Vital, reduces discomfort from osteoarthritis of the knee and hip. This study aims to investigate the impact of the same rose-hip powder (RHP) on discomfort and the consumption of rescue medication, in patients with osteoarthritis of the hand. Methods: The double blind, placebo-controlled, crossover trial included 30 patients with osteoarthritis of the dominant hand. Patients were randomly allocated to treatment with either five gram encapsulated RHP or placebo, for three months (Phase 1), after which they switched to the corresponding treatment for a further three months period (Phase 2). Before entering the study, after 3 weeks and following three months of each of the study phases, scores for pain, stiffness and general feeling of discomfort were evaluated using a 10 step categorical scale, focusing on 16 different daily activities of the hand. The consumption of rescue medication was also calculated at the beginning and at the end of each study phase. Data are based on the intention to treat. Results: At the end of Phase 1, 90% of patients in the group receiving RHP first (group A), showed a reduction in pain, as compared to 36% in the group B initially given placebo (p < 0.029). In line with this observation, stiffness and the general feeling of discomfort from the disease declined during RHP treatment (p < 0.032). In group A, symptom reduction was still indicated by the study subjects 3 weeks after the switch to placebo. The consumption of rescue medication such as paracetamol, codeine and tramadol also declined significantly in group A when compared to group B (p < 0.013). Conclusion: The present data suggest that administration of RHP, containing seeds and shells can reduce symptoms of osteoarthritis of the hand and consumption of rescue medication.

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K. Winther, J. Campbell-Tofte and P. Hansen, "Rose Hip Powder That Contains the Natural Amount of Shells and Seeds Alleviates Pain in Osteoarthritis of the Dominant Hand—A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Clinical Trial," Open Journal of Rheumatology and Autoimmune Diseases, Vol. 3 No. 3, 2013, pp. 172-180. doi: 10.4236/ojra.2013.33027.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] M. Blumenthal, W. R. Busse, A. Goldberg, J. Gruenwald, T. Hall, S. Klein, C. W. Riggins and R. S. Rister, “The Complete German Commission E Monographs, Therapeutic Guide to Herbal Medicines,” American Botanical Council, Boston, 1998.
[2] E. Rein, A. Kharazmi and K. Winther, “A Herbal Remedy, Hyben Vital (stand. Powder of Rosa canina Fruits), Reduces Pain and Improves General Wellbeing in Patients with Osteoarthritis—A Double-Blind, Placebo-Controlled, Randomised Trial,” Phytomedicine, Vol. 11, No. 5, 2004, pp. 383-391. doi:10.1016/j.phymed.2004.01.001
[3] O. Warholm, S. Skaar, E. Hedman, H. M. Molmen and L. Eik, “The Effect of a Standardized Herbal Remedy Made from a Subtype of Rosa canina in Patients with Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial,” Current Therapeutic Research, Vol. 64, No. 1, 2003, pp. 21-31. doi:10.1016/S0011-393X(03)00004-3
[4] K. Winther, K. Apel and G. A. Thamsborg, “A Powder Made from Seeds and Shells of a Rose Hip Subspecies (Rosa canina) Reduces Symptoms of Knee and Hip Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial,” Scandinavian Journal of Rheumatology, Vol. 34, No. 4, 2005, pp. 302-308. doi:10.1080/03009740510018624
[5] S. N. Willich, K. Rossnagel, S. Roll, A. Wagner, O. Mune, J. Erlendson, A. Kharazmi, H. S?rensen and K. Winther, “Rose Hip Herbal Remedy in Patients with Rheumatoid Arthritis—A Randomized Controlled Trial,” Phytomedicine, Vol. 17, No. 2, 2010, pp. 87-93. doi:10.1016/j.phymed.2009.09.003
[6] E. Harris Jr., “Pathogenesis of Rheumatoid Arthritis: A Disorder Associated with Dysfunctional Immunoregulation,” In: J. H. Gallin, I. M. Goldstein and R. Snyderman, Eds., Inflammation. Basic Principles and Clinical Correlates, Raven Press, New York, 1988, pp. 751-773.
[7] M. C. Hochberg, R. D. Altman, K. D. Brandt, B. M. Clark, P. A. Dieppe, M. R. Griffin, W. Moskowitz and T. J. Schnitzer, “Guidelines for the Medical Management of Osteoarthritis (Parts 1 and 2),” Arthritis & Rheumatism, Vol. 38, 1995, pp. 1533-1546.
[8] J. R. Vane and R. M. Botting, “Anti-Inflammatory Drugs and Their Mechanisms of Action,” Inflammatory Research, Vol. 47, 1998, pp. 578-587.
[9] M. R. Griffin, J. M. Piper, J. R. Daugherty, M. Snowden and W. A. Ray, “Nonsterioidal Anti-Inflammatory Drug Use and Increased Risk for Peptic Ulcer Disease in Elderly Persons,” Annals of Internal Medicine, Vol. 114, 1991, pp. 257-263. doi:10.7326/0003-4819-114-4-257
[10] D. Mukherjee, S. E. Nissen and E. J. Topol, “Risk of Cardiovascular Events Associated with Selective Cox-2 Inhibitors,” Journal of the American Medical Association, Vol. 286, No. 8, 2001, pp. 954-959. doi:10.1001/jama.286.8.954
[11] F. E. Silverstein, G. Faich, J. L. Goldstein, L. S. Simon, T. Pincus, A. Whelton, R. Makuch, G. Eisen, N. M. Agrawal, W. F. Stenson, A. M. Burr, W. W. Zhao, J. D. Kent, J. B. Lefkowith, K. M. Verburg and G. S. Geis, “Gastrointestinal Toxicity with Celecoxib vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis. The CLASS Study: A Randomized Controlled Trial,” Journal of the American Medical Association, Vol. 284, 2000, pp. 1247-1255. doi:10.1001/jama.284.10.1247
[12] G. H. Gislason, S. Jacobsen, J. N. Rasmussen, S. Rasmussen, P. Buch, J. Friberg, T. K. Schramm, S. Z. Abildstrom, L. K?ber, M. Madsen and C. Torp-Pedersen, “Risk of Death or Reinfarction Associated with the Use of Selective Cyclooxygenase-2 Inhibitors and Nonselective Nonsteroidal Anti-Inflammatory Drugs after Acute Myocardial Infarction,” Circulation, Vol. 27, 2006, pp. 2906-2913. doi:10.1161/CIRCULATIONAHA.106.616219
[13] L. A. C. Rodrigues and S. Hernandes-Diaz, “Relative Risk of Upper Gastrointestinal Complications among Users of Acetaminophen and Non-steroidal Anti-inflammatory Drugs,” Epidemiology, Vol. 12, No. 5, 2001, pp. 570-576. doi:10.1097/00001648-200109000-00018
[14] K. Winther, E. Rein and A. Kharazmi, “The Anti-Inflammatory Properties of Rose Hip,” Inflammopharmacology, Vol. 7, No. 1, 1999, pp. 63-68. doi:10.1007/s10787-999-0026-8
[15] A. Kharazmi and K. Winther, “Rose-Hip Inhibits Chemotaxis and Chemiluminescence of Human Blood Neutrophils in Vitro and Reduces Certain Inflammatory Parameters in Vivo,” Inflammopharmacology, Vol. 7, No. 4, 1999, pp. 377-386. doi:10.1007/s10787-999-0031-y
[16] E. Larsen, A. Kharazmi, L. P. Christensen and S. B. Christensen, “An Anti-Inflammatory Galactolipid from Rose Hip (Rosa canina L.) That Inhibits Chemotaxis of Human Peripheral Blood Neutrophils in Vitro,” Journal of Natural Products, Vol. 66, 2003, pp. 994-995. doi:10.1021/np0300636
[17] J. Schwager, U. Hoeller, S. Wolfram and N. Richard, “Rose Hip and Its Constituent Galactolipids Confer Cartilage Protection by Modulating Cytokine and Chemokine Expression,” BMC Complementary and Alternative Medicine, Vol. 11, 2011, p. 105. doi:10.1186/1472-6882-11-105
[18] R. Altman, G. Alarcon, D. Appelrouth, D. Bloch, D. Borenstein, K. Brandt, et al., “The American College of Rheumatology Criteria for the Classification and Reporting of Osteoarthritis of the Hand,” Arthritis and Rheumatism, Vol. 33, No. 11, 1990, pp. 1601-1610. doi:10.1002/art.1780331101
[19] L. Recht, T. Lithman, J. O. Rasmussen and F. K. Mathiesen, “Self-Test for Detection of Hand Dysfunction in Population Studies,” Practitioner, Vol. 232, 1988, pp. 1236-1239.
[20] K. Eberhardt, L. Recht, T. Lithman, B. Schersten, F. Wollheim and H. Petterson, “Detection of Suspected Inflammatory Joint Disease with a New Self-administered Hand Test,” British Journal of Rheumatology, Vol. 27, 1988, pp. 457-461. doi:10.1093/rheumatology/27.6.457
[21] R. D. Altman and K. C. Marcussen, “Effect of a Ginger Extract on Knee Pain in Patients with Osteoarthrosis,” Arthritis and Rheumatism, Vol. 44, 2001, pp. 2531-2538. doi:10.1002/1529-0131(200111)44:11<2531::AID-ART433>3.0.CO;2-J
[22] T. Appelboom, J. Schuermans, G. Verbruggen, Y. Henrotin and J. Y. Reginster, “Symptoms Modifying Effect of Avocado/Soybean Unsaponifiables (ASU) in Knee Os- teoarthritis,” Scandinavian Journal of Rheumatology, Vol. 30, No. 4, 2001, pp. 242-247. doi:10.1080/030097401316909602
[23] R. Christensen, E. M. Bartels, R. D. Altman, A. Astrup and H. Bliddal, “Does the Hip Powder of Rosa canina (Rosehip) Reduce Pain in Osteoarthritis Patients? A Meta-Analysis of Randomized Controlled Trials,” Osteoarthritis and Cartilage, Vol. 16, No. 9, 2008, pp. 965-972. doi:10.1016/j.joca.2008.03.001
[24] T. E. McAlindon, P. Jacques, Y. Zhang, M. T. Hannan, P. Aliabadi, B. Weissman, D. Rush, D. Levy and D. T Felson, “Do Antioxidant Micronutrients Protect against the Development and Progression of Knee Osteoarthritis?” Arthritis and Rheumatism, Vol. 39, No. 4, 1996, pp. 648-656. doi:10.1002/art.1780390417
[25] L. J. Leventhal, E. G. Boyce and R. B. Zurier, “Treatment of Rheumatoid Arthritis with Gammalinolenic Acid,” Annals of Internal Medicine, Vol. 119, No. 9, 1993, pp. 867-873. doi:10.7326/0003-4819-119-9-199311010-00001

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