KF-Al2O3 as an Efficient and Recyclable Basic Catalyst for the Synthesis of 4H-Pyran-3-carboxylates and 5-Acetyl-4H-pyrans


KF-Al2O3 as a recyclable basic catalyst for the three-component synthesis of 4H-pyran derivatives by the reaction of aldehydes, malononitrile and active methylene dicarbonyl compounds in ethanol at room temperature is described. The protocol is environmentally benign and offers rapid access to a wide array of 4H-pyran heterocycles in good to excellent yields.

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I. Kharbangar, M. Rohman, H. Mecadon and B. Myrboh, "KF-Al2O3 as an Efficient and Recyclable Basic Catalyst for the Synthesis of 4H-Pyran-3-carboxylates and 5-Acetyl-4H-pyrans," International Journal of Organic Chemistry, Vol. 2 No. 3, 2012, pp. 282-286. doi: 10.4236/ijoc.2012.23038.

Conflicts of Interest

The authors declare no conflicts of interest.


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