Salmonella enterica Modulates Its Infectivity in Response to Intestinal Stimuli

Jens Baumbach, Henrike Hoeke, Friderike Weege, Arne Gunnar Schmeisky, Petra Neumann-Staubitz

Institute for Microbiology and Genetics, Georg-August-University of Goettingen, Goettingen, Germany.

DOI: 10.4236/ojmm.2012.22006                

Abstract

En route to its intestinal target cells Salmonella enterica passes different host niches and encounters various environmental cues. These are expected to promote Salmonella in the decision of changing its extracellular life style to intracellular. We find that prior incubation of bacteria in the presence of signals which are characteristic for the small intestine affects invasion in a model system: Salmonella grown at high osmotic pressure in the presence of bile or in amino acid rich medium, infect host cells most efficiently. Hence, Salmonella enterica modulates its infectivity in response to these stimuli which consequently determines the success of infection. Our results close the current gap between signal and actual behavior and may serve as a basis for further investigations for example if Salmonella has an adaptive prediction of environmental changes.

Keywords

Environmental Signal; Intestine; Invasion

Conflicts of Interest

The authors declare no conflicts of interest.

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