A. Mitchell, G. H. Romano, B. Groisman, A. Yona, E. Dekel, M. Kupiec, O. Dahan and Y. Pilpel, “Adaptive Prediction of Environmental Changes by Microorganisms,” Nature, Vol. 460, No. 7252, 2009, pp. 220-224. doi:10.1038/nature08112

has been cited by the following article:

• TITLE: Salmonella enterica Modulates Its Infectivity in Response to Intestinal Stimuli

  AUTHORS: Jens Baumbach, Henrike Hoeke, Friderike Weege, Arne Gunnar Schmeisky, Petra Neumann-Staubitz

  KEYWORDS: Environmental Signal; Intestine; Invasion

  JOURNAL NAME: Open Journal of Medical Microbiology, Vol.2 No.2, June 12, 2012

  ABSTRACT: En route to its intestinal target cells Salmonella enterica passes different host niches and encounters various environmental cues. These are expected to promote Salmonella in the decision of changing its extracellular life style to intracellular. We find that prior incubation of bacteria in the presence of signals which are characteristic for the small intestine affects invasion in a model system: Salmonella grown at high osmotic pressure in the presence of bile or in amino acid rich medium, infect host cells most efficiently. Hence, Salmonella enterica modulates its infectivity in response to these stimuli which consequently determines the success of infection. Our results close the current gap between signal and actual behavior and may serve as a basis for further investigations for example if Salmonella has an adaptive prediction of environmental changes.