ABSTRACT
The present study was
carried out to determine LC50 of
deltamethrin (DM) in the African catfish; Clarias
gariepinus, investigate its effects on the biochemical parameters and the
antioxidant status of various tissues, and assess the protective role of Spirulina platensis (SP) against DM induced toxicity in C. gariepinus. The fish were
distributed into seven groups of 10 fish/each for 30 days as follows: Group 1,
control; Group 2, orally administered saline; Group 3, oral SP (150 mg/kg
b.w.); Group 4, exposed to 5.19 μg/l DM; Group 5, exposed to 5.19 μg/l DM and
orally administered SP (150 mg/kg b.w.); Group 6, exposed to 12.97 μg/l DM; and
Group 7, exposed to 12.97 μg/l DM and orally administered SP (150 mg/kg b.w.).
Results revealed marked elevation in serum AST, ALT, ALP, creatinine, urea and uric
acid. Significant decrease in serum total protein and albumin was recorded. At
the same time, the level of malondialdehyde (MDA) was significantly increased
in liver, kidney and gills. While, tissue level ofGSHand, SOD,CATandGSH-Px
activities were reduced. Treatment with SP improved the biochemical parameters
and attenuated the DM induced oxidative damage. Therefore, this study confirmed
the protective role of SP as an antioxidant against the toxicity of DM in
catfish.