Author(s)

Bin Hong, Qiong Cheng

Department of biological and Chemical Engineering, Jiaxing University, Jiaxing, China.
Department of Petrochemical Engineering, Changzhou University, Changzhou, China.

A novel CS-dispersed graphene modified glassy carbon electrode was fabricated. Study electrochemical characteristics of mitoxantrone in the CS-dispersed graphene modified electrode by cyclic voltammetry and other methods, by selecting and optimizing the various parameters to create a new electrochemical method for the determination of mitoxantrone. The linear range of the oxidation peak current is from 6×10–10 to 1 ×10–6 mol/l in this method, after 2.5 mins open-circuit accumulation, the limit of detection is 2×10–10 mol/l. After 10 parallel determinations, the relative standard deviation was 3.7% that the concentration of mitoxantrone was 1×10–8 mol/l. The modified electrode has been successfully applied for the assay of mitoxantrone in human urine samples.

Mitoxantrone; CS-Dispersed Graphene; Modified Electrode; Voltammetry

B. Hong and Q. Cheng, "Sensitive Voltammetric Determination of Mitoxantrone by Using CS-Dispersed Graphene Modified Glassy Carbon Electrodes," Advances in Chemical Engineering and Science, Vol. 2 No. 4, 2012, pp. 453-460. doi: 10.4236/aces.2012.24055.