Under the background of big data, the teaching reform of statistics course is carried out. Starting from the current teaching situation, centering on the fundamental purpose of “building MORALITY and cultivating people”, the scientific curriculum system and knowledge points are reshaped and the teaching mode is reformed. Through several years of practice and exploration, the research group has innovated the teaching model and reformed the assessment method by renewing the teaching idea, reconstructing the teaching strategy and integrating the teaching content, and achieved obvious teaching effects.