Design and Synthesis of Some New Oxadiazole Derivatives as Anticancer Agents - International Journal of Organic Chemistry

IJOC > Vol.12 No.2, June 2022

International Journal of Organic Chemistry

Volume 12, Issue 2 (June 2022)

ISSN Print: 2161-4687 ISSN Online: 2161-4695

Google-based Impact Factor: 1.15 Citations

Design and Synthesis of Some New Oxadiazole Derivatives as Anticancer Agents ()

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DOI: 10.4236/ijoc.2022.122006 367 Downloads 1,798 Views Citations

Author(s)

Mo’men Salem¹, Rezk Ayyad², Helmy Sakr²

Affiliation(s)

¹Department of Medicinal Chemistry, Faculty of Pharmacy, Sinai University, Northern Sinai, Egypt.
²Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

ABSTRACT

In this work, some new oxadiazole derivatives have been prepared, by reacting phenyl hydrazine and acetic anhydride together, which furnished 2,4-dimethyl-4-phenyloxadiazole. This product was reacted with a series of aromatic aldehydes, to obtain a series of oxadiazole derivatives. These derivatives were characterized by TLC, melting points, infrared red, proton nuclear magnetic resonance, carbon thirteen nuclear magnetic resonance and mass spectroscopy. Finally, these synthetized derivatives were tested for antiproliferative activity by two different cell lines. MCF-7 (Breast cancer cell line) and HepG2 (Liver cancer cell line) were used to assess the antiproliferative activity of the prepared compounds.

KEYWORDS

Phenyl Hydrazine, Oxadiazole, Aromatic Aldehydes, Acetic Anhydride, Benzylidene Synthesis, Cytotoxic Assay, Anticancer, HepG2 and MCF-7

Share and Cite:

Salem, M. , Ayyad, R. and Sakr, H. (2022) Design and Synthesis of Some New Oxadiazole Derivatives as Anticancer Agents. International Journal of Organic Chemistry, 12, 64-74. doi: 10.4236/ijoc.2022.122006.

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