Effects of γ-Polyglutamic Acid on Blood Glucose and Caecal Short Chain Fatty Acids in Adult Male Mice - Food and Nutrition Sciences

FNS > Vol.11 No.1, January 2020

Food and Nutrition Sciences

Volume 11, Issue 1 (January 2020)

ISSN Print: 2157-944X ISSN Online: 2157-9458

Google-based Impact Factor: 0.92 Citations h5-index & Ranking

Effects of γ-Polyglutamic Acid on Blood Glucose and Caecal Short Chain Fatty Acids in Adult Male Mice ()

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DOI: 10.4236/fns.2020.111002 671 Downloads 1,842 Views Citations

Author(s)

Motoi Tamura^*, Sachiko Hori, Atsuko Inose, Masuko Kobori

Affiliation(s)

Food Function Division, Food Research Institute of National Agriculture and Food Research Organization Tsukuba, Ibaraki, Japan.

ABSTRACT

γ-Polyglutamic acid (γ-PGA) is a major component of Natto. We hypothesized that γ-PGA could reduce postprandial glucose rise and plasma glucose levels. Mice were fed a 0.1% γ-PGA—containing diet or control diet for 91 days. Maltose and starch tolerance tests were performed, and plasma lipids, glucose levels, and caecal short chain fatty acids (SCFAs) were measured. Mice were co-administered γ-PGA and starch to suppress the initial rise in blood glucose levels. Blood glucose levels at 15 min were significantly lower in the PGA group than in the Con group (P < 0.05). The plasma glucose level and NEFA level were also significantly lower in the PGA group (P < 0.05), and caecal acetic acid/total caecal SCFAs ratio was significantly increased in the PGA group (P < 0.05). Significant negative correlations existed between the caecal acetic acid/propionic acid ratio and the weight of visceral fat/BW (r = -0.57, P = 0.0318). Our results suggest that γ-PGA may effectively prevent metabolic syndrome by lowering blood glucose levels.

KEYWORDS

γ-Polyglutamic Acid, Mice, Blood Glucose, Short Chain Fatty Acids

Share and Cite:

Tamura, M. , Hori, S. , Inose, A. and Kobori, M. (2020) Effects of γ-Polyglutamic Acid on Blood Glucose and Caecal Short Chain Fatty Acids in Adult Male Mice. Food and Nutrition Sciences, 11, 8-22. doi: 10.4236/fns.2020.111002.

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