Journal of Biosciences and Medicines

Volume 3, Issue 3 (March 2015)

ISSN Print: 2327-5081   ISSN Online: 2327-509X

Google-based Impact Factor: 0.82  Citations  

Influence of Genetic Polymorphism of Styrene-Metablizing Enzymes on Occupational Exposure Monitoring to Styrene

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DOI: 10.4236/jbm.2015.33005    3,199 Downloads   3,545 Views  
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ABSTRACT

In this study, we selected 58 styrene-exposed workers, measured personal styrene exposure, evaluated genotypes relevant drug-metabolizing enzymes (CYP2E1, EPHX1, GSTM1 and GSTT1) which may explain the variability in the urinary metabolite excretion. The results showed that, in different levels of styrene exposure groups, there is a significant association between urinary metabolites and some genotypes of styrene-metabolizing enzymes, including CYP2E1 (5-flanking region, RsaI/PstI), GSTM1(gene deletions) and EPHX1(predicted activity).

Cite this paper

Qu, W. and Zhang, F. (2015) Influence of Genetic Polymorphism of Styrene-Metablizing Enzymes on Occupational Exposure Monitoring to Styrene. Journal of Biosciences and Medicines, 3, 35-38. doi: 10.4236/jbm.2015.33005.

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