Phase Transfer Catalysis Improved Synthesis of 3,4-Dihydropyrimidinones - International Journal of Organic Chemistry

IJOC > Vol.3 No.3, November 2013

International Journal of Organic Chemistry

Volume 3, Issue 3 (November 2013)

ISSN Print: 2161-4687 ISSN Online: 2161-4695

Google-based Impact Factor: 1.26 Citations

Phase Transfer Catalysis Improved Synthesis of 3,4-Dihydropyrimidinones ()

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DOI: 10.4236/ijoc.2013.33A009 7,163 Downloads 14,714 Views Citations

Author(s)

Hela Slimi, Khemaïs Saïd, Younes Moussaoui, Ridha Ben Salem

Affiliation(s)

Physical Organic Chemistry Laboratory (UR11ES74), Science Faculty of Sfax, Sfax University, Sfax, Tunisia.
Physical Organic Chemistry Laboratory (UR11ES74), Science Faculty of Sfax, Sfax University, Sfax, Tunisia Science Faculty of Gafsa, Gafsa University, Gafsa, Tunisia.

ABSTRACT

Various 3,4-dihydropyrimidinones can be prepared via Biginelli reaction in aqueous media by using quaternary ammonium salts of different alkyl groups (C4 and C8) and anions (Cl^- and Br^-) as catalysts. The use of quaternary ammonium salts along with longer alkyl chains increases the yield of the Biginelli reaction; however, bromide ammonium salts are less active than the chloride ones.

KEYWORDS

Multicomponent Reaction; Biginelli Reaction; 3, 4-Dihydropyrimidinones; Phase-Transfer Catalysis; Quaternary Ammonium Salts

Share and Cite:

Slimi, H. , Saïd, K. , Moussaoui, Y. and Salem, R. (2013) Phase Transfer Catalysis Improved Synthesis of 3,4-Dihydropyrimidinones. International Journal of Organic Chemistry, 3, 96-100. doi: 10.4236/ijoc.2013.33A009.

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