Influence of Omega 3 Fatty Acid Supplementation on Phase Angle Values of People Living with HIV/AIDS with Lipodystrophy Secondary to Antiretroviral Therapy: A Randomized Clinical Trial ()
Affiliation(s)
1Núcleo de Medicina Tropical do Pará, Programa de Pós graduação em Patologia das Doenças Tropicais, Universidade Federal do Pará, Pará, Brasil.
2Instituto de Ciências Biológicas e da Saúde, Faculdade de Medicina, Universidade Federal do Pará, Pará, Brasil.
3Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Pará, Pará, Brasil.
ABSTRACT
Objective: The measurement of phase angles is an important monitoring parameter and
supplementation with omega-3 could promote benefits by modulating the
electrical potential of membranes and increasing body cell mass. This study
aimed to evaluate the effectiveness of omega-3 fatty acid supplementation on
the phase angle of people living with HIV/AIDS. Methods: In this study,
63 individuals of all genders who were undergoing outpatient follow-up and
showed lipodystrophy due to highly active antiretroviral therapy were analyzed.
Our sample consisted of two groups, one that received supplementation
containing 2550 mg of omega-3/day (1080 mg of eicosapentaenoic acid and 720 mg
of docosahexaenoic acid) for three months (n = 32) and another that underwent
nutrition guidance (n = 31). Phase angle and body cell mass were assessed for
both groups and compared at the beginning of research (T0) and after our
intervention (T1) for each group separately. Results: Phase angle
averaged 6.45° ± 1.06 SD. The comparison between T0 and T1 showed a
significant increase in phase angle and body cell mass, whereas the guidance
group showed a decrease in body cell mass at T1 in relation to T0, with a
significant p-value. Variance in phase angle between moments showed significant
values between T0 and T1 in the supplementation group for all genders. Conclusion: Omega-3 positively modulated patients phase angle and body cell mass, but
we emphasize the need for other studies that can solidify knowledge about
supplementation dosage and intervention time.
Share and Cite:
Dantas, T. , Castro, A. , de Souza Flexa Ribeiro Filho, F. and Libonati, R. (2024) Influence of Omega 3 Fatty Acid Supplementation on Phase Angle Values of People Living with HIV/AIDS with Lipodystrophy Secondary to Antiretroviral Therapy: A Randomized Clinical Trial.
Food and Nutrition Sciences,
15, 58-70. doi:
10.4236/fns.2024.151003.
Cited by
No relevant information.