Oxone-Mediated Preparation of Ester Derivatives Using Indium(III) Triflate and Various Alcohols - Green and Sustainable Chemistry

GSC > Vol.12 No.1, February 2022

Green and Sustainable Chemistry

Volume 12, Issue 1 (February 2022)

ISSN Print: 2160-6951 ISSN Online: 2160-696X

Google-based Impact Factor: 0.71 Citations

Oxone-Mediated Preparation of Ester Derivatives Using Indium(III) Triflate and Various Alcohols ()

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DOI: 10.4236/gsc.2022.121001 274 Downloads 1,101 Views

Author(s)

Tomoko Mineno^1*, Daiki Takano¹, Saika Komiya¹, Azusa Sato¹, Hisao Kansui²

Affiliation(s)

¹Laboratory of Medicinal Chemistry, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Gunma, Japan.
²Laboratory of Organic Chemistry, Faculty of Pharmaceutical Sciences, Sojo University, Ikeda, Kumamoto, Japan.

ABSTRACT

Esters are known as one of the most fundamental chemical moieties and also essentially useful components, especially for medicinal agents. Herein, using benzaldehyde and its derivatives as starting materials, Oxone-mediated preparation of ester derivatives in the presence of a catalytic amount of indium(III) triflate is described. Alcohols with various chain lengths, which functioned as solvents and substrates, were examined. Overall, the oxidative esterification starting with benzaldehyde derivatives possessing electron withdrawing groups proceeded smoothly and gave sufficient yields, in comparison to the reactions with the derivatives having electron donating groups.

KEYWORDS

Oxone, Oxidative Esterification, Benzaldehyde Derivatives, Ester Derivatives, Indium(III) Triflate, Alcohols

Share and Cite:

Mineno, T. , Takano, D. , Komiya, S. , Sato, A. and Kansui, H. (2022) Oxone-Mediated Preparation of Ester Derivatives Using Indium(III) Triflate and Various Alcohols. Green and Sustainable Chemistry, 12, 1-8. doi: 10.4236/gsc.2022.121001.

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