Author(s)

Francis A. Ngounoue Kamga¹, Evans Ngandung Mainsah², Maurice Kuate¹, Peter T. Ndifon^1*

¹Department of Inorganic Chemistry, Faculty of Science, University of Yaounde I, Yaoundé, Cameroon.
²Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon.

The Schiff base, 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L₁) has been synthesized by the condensation reaction between 2-aminopyrimidine and 2-benzoylpyridine and characterized using ¹³C-NMR, ¹H-NMR, microanalysis, FT-IR, DEPT-135, HSQC, HMBC, COZY, NOESY. The reaction of 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L₁) with salts of V(IV), Co(II) and Cu(II), however, resulted in the hydrolysis of L₁ to give binuclear metal complexes of 2-benzoylpyridine (L₂) and phenyl(pyridin-2-yl)methanediol (L₃) which were characterized using UV-visible spectroscopy, and TGA. The single crystal x-ray structure determined for the Copper(II) complex revealed that we obtained a compound previously obtained using a different method of synthesis. The Schiff base ligand (L₁) is soluble in methanol, ethanol, DMSO, acetone and DMF. Microanalysis and Spectroscopic studies indicated that binuclear metal complexes were obtained by the coordination of metal ion to 2-benzoylpyridine (L₂) and phenyl(pyridin-2-yl)methanediol (L₃) from the hydrolysis of L₁. Spectroscopic and elemental analysis reveal the formation of square pyramidal complexes of Co(II) and Cu(II) and a square planar complex of V(IV). In vitro antibacterial and antifungal activity against three bacterial strains (Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus) and three fungal stains (Candida albicans, Candida glabrata and Candida parapsilosis) showed moderate biological activity. Antioxidant studies reveal that only the binuclear Co(II) and oxovanadium(II) complexes are potent to eliminate free radicals.

Binuclear Complexes, Schiff Base, 2-Benzoylpyridine, Crystal Structure, Antimicrobial Activity, Antioxidant Activity

Kamga, F. , Mainsah, E. , Kuate, M. and Ndifon, P. (2021) Synthesis, Characterization and Biological Activities of Binuclear Metal Complexes of 2-Benzoylpyridine and Phenyl(Pyridin-2-yl) Methanediol Derived from 1-Phenyl-1-(Pyridin-2-yl)-N-(Pyrimidin-2-yl) Methanimine Dihydrate Schiff Base. Open Journal of Inorganic Chemistry, 11, 20-42. doi: 10.4236/ojic.2021.111002.