Author(s)

Zuren Peng¹, Wanying Wang², Xianjun Long¹, Ping Qiu¹, Qiaoqiao Liu¹, Yuanxiang Yang¹, Xuechun Yang¹, Meili Wang¹, Songmao Yin¹, Xingchu Gong^2*

¹Hunan Zhenqin Pharmaceutical Group Co., Ltd., Huaihua, China.
²Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Continuous manufacturing is considered as one of the future trends of pharmaceutical engineering. In this work, continuous liquid-liquid extraction for sinomenine purification was realized with the usage of centrifugal extractors. Chloroform was used as the extractant because of the high distribution coefficient (>100). Higher extraction ratio can be obtained when using the centrifugal extractor of Model CWL50-N. The extraction ratio of the second-stage extraction was higher than that of the first-stage extraction. The extraction ratio of the second-stage countercurrent extraction was higher than that of second-stage cross-flow extraction. When chloroform phase was recycled for liquid-liquid extraction, the extraction ratio was also higher than 95%. This work can also be an example of continuous liquid-liquid extraction for the separation of other Chinese medicine components.

Sinomenine, Continuous Manufacturing, Liquid-Liquid Extraction, Centrifugal Extractor

Peng, Z. , Wang, W. , Long, X. , Qiu, P. , Liu, Q. , Yang, Y. , Yang, X. , Wang, M. , Yin, S. and Gong, X. (2020) Sinomenine Purification by Continuous Liquid-Liquid Extraction Process with Centrifugal Extractors. Advances in Chemical Engineering and Science, 10, 171-180. doi: 10.4236/aces.2020.103012.