Antioxidant and Neuroprotective Activities of the Mesocarp of Raphia hookeri Fruit against Aluminum Chloride-Induced Neurotoxicity in Rats ()
Affiliation(s)
1Research Unit of Biochemistry, Medicinal Plants, Food Sciences and Nutrition, Department of Biochemistry, University of Dschang, Dschang, Cameroon.
2Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde I, Yaounde, Cameroon.
ABSTRACT
This work aims to evaluate the antioxidant and protective effect of Raphia hookeri (Rh) fruit extracts and powders against aluminum induced neurotoxicity in
rats. Extracts and powder were prepared using fruit mesocarp. Phytochemical
contents (phenolic content and flavonoïd) and antioxidant in vitro activity were evaluated through the DPPH radical scavenging capacity,
the ability to reduce ferric ion and Hydroxyl radical scavenging ability. The
neurocognitive dysfunction, the activity of acetylcholinesterase (AChE) and
activities of antioxidant in vivo indices were evaluated in the plasma, liver and brain of aluminum
chloride (AlCl3) induced neurotoxicity in rats. The
highest total phenolic (76.34 mg Eq AG/g of extract), flavonoïds’
contents (13.32 mg Eq CAT/g of extract), the best DPPH scavenging activity and
the ability to reduce ferric ion (Fe3+) were obtained with aqueous
extract. The administration of aqueous extract (200 and 400 g/kg bw) and powder
(5% and 10 %) during 28 days resulted in a significant decrease (P < 0.05) of the time use to find platform and the increase of the
acquisition speed of food in rats. Also the evaluation of some biochemical
parameters shows the decrease of malondialdehyde, nitric oxide and
acetylcholine esterase activity and the increase of total protein level,
catalase activities (CAT), superoxide dismutase (SOD) and glutathione level in
plasma, liver and brain compared to the positive control group (PC). The best
activities were obtained with groups ARh400 and Rh10%. Treatment
with aqueous extract and powder of Rh mesocarp ameliorated neurobehavioral
changes by enhancing antioxidant activities, cognitive functions. Therefore Rh would
protect oxidative damage and preserve neurone functions.
Share and Cite:
Doungue, H. , Kengne, A. and Womeni, H. (2020) Antioxidant and Neuroprotective Activities of the Mesocarp of
Raphia hookeri Fruit against Aluminum Chloride-Induced Neurotoxicity in Rats.
Food and Nutrition Sciences,
11, 396-415. doi:
10.4236/fns.2020.115029.
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