Author(s)

Pablo A. Martínez-Soriano^1*, José R. Macías-Pérez², Ana María Velázquez¹, Brígida del Carmen Camacho-Enriquez¹, Gustavo Pretelín-Castillo¹, Mónica B. Ruiz-Sánchez¹, Víctor H. Abrego-Reyes³, Saúl Villa-Treviño², Enrique Angeles¹

¹Laboratorio de Química Medicinal y Teórica, Departamento de Ciencias Químicas, FES Cuautitlán, Universidad Nacional Autónoma de México, Cuautitlán Izcalli, México.
²Departamento de Biología celular, Centro de Investigación y Estudios Avanzados, Instituto Politécnico Nacional, México, D.F., México.
³Qsar Analytics S.A. de C.V. Ciudad Satélite, Naucalpan de Juárez, México.

A convenient and easy method is described for the formation of carboxamides from carboxylic acids and primary amines in solventless conditions using infrared (IR) light. Thus, under IR light, cinnamic acid derivatives and amines can produce yields ranging from 50% to 85% of the resulting amide.

Amides, Carboxylic Acids, Amines, Infrared Light, Solventless, CAPE, CAPA, Cinnamic Acid Analogs

Martínez-Soriano, P. , Macías-Pérez, J. , Velázquez, A. , Camacho-Enriquez, B. , Pretelín-Castillo, G. , Ruiz-Sánchez, M. , Abrego-Reyes, V. , Villa-Treviño, S. and Angeles, E. (2015) Solvent-Free Synthesis of Carboxylic Acids and Amide Analogs of CAPE (Caffeic Acid Phenethyl Ester) under Infrared Irradiation Conditions. Green and Sustainable Chemistry, 5, 81-91. doi: 10.4236/gsc.2015.52011.