Author(s)

Lilia Narinyan, Sinerik Ayrapetyan

UNESCO Chair—Life Sciences International Postgraduate Educational Center, Yerevan, Armenia.

Previously we have shown that 4 Hz and 8 Hz EMF exposures have depressing effect on the thermodynamic activity of water, which decreases peroxide formation. It has also been shown that 4 Hz EMF-treated physiological solution modulates the growth and development of microbes and heart muscle contractility, but 8 Hz EMF has pronounced inhibitory effect on bacterial growth and development. Therefore, in order to elucidate the possible mechanism of 4 Hz and 8 Hz EMF effects on heart muscle function, in the present work the effects of 4 Hz and 8 Hz EMF exposures on heart muscle tissue hydration, the sensitivity of 4 Hz and 8 Hz EMF-induced tissue hydration to 10⁻⁴ M ouabain (Na⁺/K⁺ pump inhibition) and 10⁻⁹ M ouabain (activation of intracellular signaling system) as well as the effects of 4 Hz and 8 Hz EMF exposures on the number of Na⁺/K⁺ pump units in the membrane of both young and old rats have been studied. The obtained data allow us to suggest that 8 Hz EMF exposure has more pronounced age-dependent modulation effect on tissue hydration of heart muscle than 4 Hz EMF and this effect is sensitive to Na⁺/K⁺ pump activity and intracellular signaling system.

EMF, Tissue Hydration, Heart, Na+/K+ Pump, Na⁺/Ca²⁺ Exchange

Narinyan, L. and Ayrapetyan, S. (2019) Age-Dependent Comparative Study of 4 Hz and 8 Hz EMF Exposure on Heart Muscle Tissue Hydration of Rats. Open Journal of Biophysics, 9, 70-82. doi: 10.4236/ojbiphy.2019.91005.