Reaction Rate Models for the Thermal Decomposition of Ibuprofen Crystals - Journal of Crystallization Process and Technology

JCPT > Vol.4 No.2, April 2014

Reaction Rate Models for the Thermal Decomposition of Ibuprofen Crystals ()

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DOI: 10.4236/jcpt.2014.42010 8,363 Downloads 12,584 Views Citations

Author(s)

Sundaram Ramukutty, Esakki Ramachandran

Affiliation(s)

Department of Physics, Thiruvalluvar College, Papanasam, India.

ABSTRACT

Kinetics of the decomposition of racemic ibuprofen crystals were studied by non-isothermal analysis. Thermogravimetric analysis revealed that ibuprofen is thermally stable up to 152.6°C and the initial loss of mass was due to evaporation only. Activation energy, pre-exponential factor, activation entropy and Gibbs free energy for the decomposition of ibuprofen were determined using the integral method of Coats-Redfern (CR). Geometrical contraction models were found to be the best fits. The Arrheinus equation for the thermal decomposition of ibuprofen is k = (1.1 × 10⁷) e^–79125/RT sec^–1.

KEYWORDS

Ibuprofen, Model Fitting, Kinetics, Decomposition, Coats-Redfern Method

Share and Cite:

Ramukutty, S. and Ramachandran, E. (2014) Reaction Rate Models for the Thermal Decomposition of Ibuprofen Crystals. Journal of Crystallization Process and Technology, 4, 71-78. doi: 10.4236/jcpt.2014.42010.

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