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Reaction Rate Models for the Thermal Decomposition of Ibuprofen Crystals

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DOI: 10.4236/jcpt.2014.42010    5,395 Downloads   7,085 Views   Citations

ABSTRACT

Kinetics of the decomposition of racemic ibuprofen crystals were studied by non-isothermal analysis. Thermogravimetric analysis revealed that ibuprofen is thermally stable up to 152.6°C and the initial loss of mass was due to evaporation only. Activation energy, pre-exponential factor, activation entropy and Gibbs free energy for the decomposition of ibuprofen were determined using the integral method of Coats-Redfern (CR). Geometrical contraction models were found to be the best fits. The Arrheinus equation for the thermal decomposition of ibuprofen is k = (1.1 × 107) e–79125/RT sec–1.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Ramukutty, S. and Ramachandran, E. (2014) Reaction Rate Models for the Thermal Decomposition of Ibuprofen Crystals. Journal of Crystallization Process and Technology, 4, 71-78. doi: 10.4236/jcpt.2014.42010.

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