Author(s)

D. Babarykin^1*, M. Mutalova¹, G. Smirnova^1,2, S. Vasiljeva², G. Krumina¹, N. Basova², V. Agejchenko¹, R. Simanis³

¹Institute of Innovative Biomedical Technology Ltd., Riga, Latvia.
²Institute of Biology of the University of Latvia, Salaspils, Latvia.
³Riga Stradins University, Riga, Latvia.

Despite the market saturation with a wide range of calcium preparations in dietary supplements as well as in pharmaceuticals, calcium product safety and efficacy remain an item for further optimization. Bones and teeth mainly consist of calcium phosphate, but tablets and capsules are predominantly produced from calcium carbonate. On the other hand, in human food Ca²⁺ is bound with a lot of anions—carbonates, sulphates, chlorides, phosphates, citrates, oxalates etc. It seems that traditional calcium formulations due its low bioavailability cannot provide all spectra of biological calcium-dependant effects and dietary calcium might be safer and more effective than traditional calcium supplements and medicines. To increase calcium salt efficacy a new formulation of calcium salts has been developed. It is a mixture (water suspension) of amorphous calcium carbonate, citrate, hydrocarbonate, as well as magnesium hydrocarbonate and hydrocitrate as stabilizers. The capacity of a cockerel’s duodenal mucosa to absorb Ca²⁺ after peroral ingestion of the mentioned composition in vivo was as much as 126% higher in comparison with CaCO₃ suspension intake. Vitamin D₃ enhanced the amorphous antirachitic activity of calcium salts. The aim of the study was to compare original amorphous calcium salt composition bioavailability with Ca salts most often in food and medicines, as well as to evaluate the antirachitic activity of the mentioned composition in combination with vitamin D₃ in chickens.

Calcium Absorption, Amorphous Calcium, Experimental Rickets, Chicken

Babarykin, D. , Mutalova, M. , Smirnova, G. , Vasiljeva, S. , Krumina, G. , Basova, N. , Agejchenko, V. and Simanis, R. (2019) Amorphous Calcium Salt Composition Bioavailability Evaluation in Chickens. Journal of Biosciences and Medicines, 7, 15-25. doi: 10.4236/jbm.2019.72002.