Reactive Arrays of Colorimetric Sensors for Metabolite and Steroid Identification - Journal of Sensor Technology

JST > Vol.4 No.1, March 2014

Journal of Sensor Technology

Volume 4, Issue 1 (March 2014)

ISSN Print: 2161-122X ISSN Online: 2161-1238

Google-based Impact Factor: 2.07 Citations

Reactive Arrays of Colorimetric Sensors for Metabolite and Steroid Identification ()

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DOI: 10.4236/jst.2014.41001 3,884 Downloads 6,061 Views Citations

Author(s)

Gary Batres, Talia Jones, Hannah Johnke, Mark Wilson, Andrea E. Holmes, Sharmin Sikich

Affiliation(s)

Department Chemistry, Doane College, Crete, USA.

ABSTRACT

The work described herein examines a rapid mix-and-measure method called DETECHIP suitable for screening of steroids and metabolites. The addition of steroids and metabolites to reactive arrays of colorimetric sensors generated characteristic color “fingerprints” that were used to identify the analyte. A color analysis tool was used to identify the analyte pool that now includes biologically relevant analytes. The mix-and-measure arrays allowed the detection of disease metabolites, orotic acid and argininosuccinic acid; and the steroids androsterone, 1,4-androstadiene, testosterone, stanozolol, and estrone. The steroid 1,4-androstadiene was also detected by this method while dissolved in synthetic urine. Some of the steroids, such as androstadiene, stanozolol, and androsterone were co-dissolved with (2-hydroxypropyl)-β-cyclodextrin in order to increase solubility in aqueous buffered solutions. The colorimetric arrays do not intend to eliminate ELISA or mass spectroscopy based screening, but to possibly provide an alternative analytical detection method for steroids and metabolites.

KEYWORDS

Colorimetric Arrays; Sensors; Color Changes; Steroids; Metabolic Disease, Metabolites, Detection

Share and Cite:

Batres, G. , Jones, T. , Johnke, H. , Wilson, M. , Holmes, A. and Sikich, S. (2014) Reactive Arrays of Colorimetric Sensors for Metabolite and Steroid Identification. Journal of Sensor Technology, 4, 1-6. doi: 10.4236/jst.2014.41001.

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