Dr. Thomas T. Y. Wang

Johns Hopkins University, USA

Email: tom.wang@ars.usda.gov

Qualifications

1986 Ph.D., Nutritional Biochemistry, University of California, USA

1982 M.Sc., Nutritional Biochemistry, University of California, USA

1979 B.Sc., Nutrition, Fu-Jen University, Chinese Taipei

Publications(Selected)

1. Leung LK, Wang TT. Bcl-2 is not reduced in the death of MCF-7 cells at low genistein concentration. J Nutr. 2000 Dec;130(12):2922-6
2. Hursting SD, Shen JC, Sun XY, Wang TT, Phang JM, Perkins SN.  Modulation of cyclophilin gene expression by N-4-(hydroxyphenyl)retinamide: association with reactive oxygen species generation and apoptosis. MolCarcinog. 2002 Jan;33(1):16-24
3. Wang TT. beta-naphthoflavone, an inducer of xenobiotic metabolizing enzymes, inhibits firefly luciferase activity. Anal Biochem. 2002 May 1;304(1):122-6
4. Po LS, Wang TT, Chen ZY, Leung LK. Genistein-induced apoptosis in MCF-7 cells involves changes in Bak and Bcl-x without evidence of anti-oestrogenic effects. Br J Nutr. 2002 Nov;88(5):463-9
5. Rosenfeld S, Wang T, Kim Y, Milner J. Numerical deconvolution of cDNA microarray signal: simulation study. Ann N Y Acad Sci. 2004 May;1020:110-23
6. Takahashi Y, Lavigne JA, Hursting SD, Chandramouli GV, Perkins SN, Barrett JC, Wang TT. Using DNA microarray analyses to elucidate the effects of genistein in androgen-responsive prostate cancer cells: identification of novel targets. MolCarcinog. 2004 Oct;41(2):108-119
7. Takahashi Y, Hursting SD, Perkins SN, Wang TC, Wang TT. Genistein affects androgen-responsive genes through both androgen- and estrogen-induced signaling pathways.MolCarcinog. 2006 Jan;45(1):18-25
8. Wang TT, Milner MJ, Milner JA, Kim YS. Estrogen receptor alpha as a target for indole-3-carbinol. J NutrBiochem. 2006 Oct;17(10):659-64. Epub 2005 Nov 28
9. Takahashi Y, Lavigne JA, Hursting SD, Chandramouli GV, Perkins SN, Kim YS, Wang TT. Molecular signatures of soy-derived phytochemicals in androgen-responsive prostate cancer cells: a comparison study using DNA microarray. MolCarcinog. 2006 Dec;45(12):943-56
10. Takahashi Y, Perkins SN, Hursting SD, Wang TT. 17beta-Estradiol differentially regulates androgen-responsive genes through estrogen receptor-beta- and extracellular-signal regulated kinase-dependent pathways in LNCaP human prostate cancer cells. MolCarcinog. 2007 Feb;46(2):117-29
11. Daly KT, Tracy AC, Malik M, Wang TT, Francke-Carroll S, Magnuson BA. Enhanced estrogenic responses and sensitivity to azoxymethane following dietary soy isoflavone supplementation in older female rats. Food ChemToxicol. 2007 Apr;45(4):628-37. Epub 2006 Nov 2
12. Trasio SE, Harrison EH, Wang TT. Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in the androgen-responsive human prostate cancer cell line LNCaP. ExpBiol Med (Maywood). 2007 Jun;232(6):762-71
13. Lavigne JA, Takahashi Y, Chandramouli GV, Liu H, Perkins SN, Hursting SD, Wang TT. Concentration-dependent effects of genistein on global gene expression in MCF-7 breast cancer cells: an oligo microarray study. Breast Cancer Res Treat. 2008 Jul;110(1):85-98. Epub 2007 Aug 9
14. Hudson TS, Hartle DK, Hursting SD, Nunez NP, Wang TT, Young HA, Arany P, Green JE. Inhibition Of Prostate Cancer Growth By Muscadine Grape Skin Extract And Resveratrol Through Distinct Mechanisms. Cancer Res. 2007 Sep 1;67(17):8396-405
15. Wang TT, Hudson TS, Wang TC, Remsberg CM, Davies NM, Takahashi Y, Kim YS, Seifried H, Vinyard BT, Perkins SN, Hursting SD. Differential Effects of Resveratrol on Androgen-responsive LNCaP Human Prostate Cancer Cells In Vitro and In Vivo. Carcinogenesis. 2008 Jun 26. [Epub ahead of print]
16. Trasino SE, Kim YS, Wang TT. Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells. Mol Cancer Ther. 2009 Jun 16. [Epub ahead of print]
17. Payton-Stewart F, Schoene NW, Kim YS, Burow ME, Cleveland TE, Boue SM, Wang TT. Molecular effects of soy phytoalexinglyceollins in human prostate cancer cells LNCaP. MolCarcinog. 2009 Mar 4. [Epub ahead of print]
18. Hawkes WC, Wang TT, Alkan Z, Richter BD, Dawson K. Selenoprotein W Modulates Control of Cell Cycle Entry. Biol Trace Elem Res. 2009 Apr 22. [Epub ahead of print]