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Preventive effect of Catharanthus roseus (Linn.) against high-fructose diet-induced insulin resistance and oxida-tive stress in male Wistar rats

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DOI: 10.4236/jdm.2011.13010    3,995 Downloads   8,406 Views   Citations

ABSTRACT

High intake of dietary fructose has been shown to exert a number of adverse metabolic effects in humans and experimental animals. The aim of the present study was to investigate whether Catharanthus roseus (L.) G. Don (Apocynaceae) leaf powder alleviates high-fructose diet-induced insulin resistance and oxidative stress in rats. Adult male Wistar rats of body weight around 200 g were divided into four groups, two of which were fed with standard pellet diet and the other two with high fructose (66%) diet. C. roseus leaf powder suspension in water (100 mg/kg body weight/day) was administered orally to each group of the standard pellet diet fed rats and the high fructose diet fed rats for 60 days. Fructose fed rats (F-group) showed hyperglycemia, hyperinsulinemia, insulin resistance and hyperlipidemia (P < 0.05). C. roseus treatment in fructose fed rats (F+CR-group) prevented the rise in glucose levels by 32.2%, insulin by 46.4%, and impaired insulin sensitivity by 63.6%. C. roseus treatment completely prevented the fructose induced plasma lipid alterations. Regarding liver antioxidant status, oxidative stress was observed in fructose fed rats (F-group), while C. roseus treatment in F+CR-group prevented the fructose induced oxidative stress. Our data indicate the preventive role of C. roseus against fructose-induced insulin resistance and oxidative stress; hence this plant can be used as an adjuvant for the prevention and/or management of insulin resistance and disorders related to it.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Rasineni, K. and Desireddy, S. (2011) Preventive effect of Catharanthus roseus (Linn.) against high-fructose diet-induced insulin resistance and oxida-tive stress in male Wistar rats. Journal of Diabetes Mellitus, 1, 63-70. doi: 10.4236/jdm.2011.13010.

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