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Metastatic peritoneal sarcomatosis from radiation-induced osteosarcoma in a patient with previously treated pelvic Ewing’s sarcoma: Report of a case

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DOI: 10.4236/ojcd.2013.32010    3,145 Downloads   5,374 Views  

ABSTRACT

Metastatic peritoneal sarcomatosis most commonly occurs from primary soft tissue sarcomas arising either within the abdomen or extremities. Metastatic peritoneal sarcomatosis from an osteosarcoma is extremely rare; only six cases have previously been reported. We report the first case of metastatic peritoneal sarcomatosis originating from radiation-induced osteoblastic osteosarcoma in a 22-year-old woman who had previously been treated for pelvic Ewing’s sarcoma. Abdominal computed tomography, bone scintigraphy and FDG PET/CT demonstrated extensive finely nodular disseminated peritoneal lesions. Histopathologic examination of these peritoneal lesions revealed osteosarcomatosis. In summary, we describe an unusual case of metastatic peritoneal sar comatosis from secondary osteosarcoma arising in a previously irradiated pelvicEwing’s sarcoma.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Kumar, R. , Patel, R. , Madewell, J. , Al-Zaid, T. and Meis, J. (2013) Metastatic peritoneal sarcomatosis from radiation-induced osteosarcoma in a patient with previously treated pelvic Ewing’s sarcoma: Report of a case. Open Journal of Clinical Diagnostics, 3, 52-56. doi: 10.4236/ojcd.2013.32010.

References

[1] Oei, T.N., Jagannathan, J.P., Ramaiya, N. and Ros, P.R. (2010) Peritoneal sarcomatosis versus peritoneal carcinomatosis: Imaging findings at MDCT. AJR American Journal of Roentgenology, 195, W229-W235. doi:10.2214/AJR.09.3907
[2] Zanarini, D. and Sugarbaker, P.H. (1997) Extremity soft tissue sarcoma with metastases to abdominopelvic surfaces. Journal of Surgical Oncology, 64, 68-72. doi:10.1002/(SICI)1096-9098(199701)64:1<68::AID-JSO13>3.0.CO;2-S
[3] Yeh, S.N. and Lu, M.Y. (2005) Peritoneal metastasis in osteosarcoma: Report of one case. Acta Paediatrica Taiwanica, 46, 230-234.
[4] Lin, J.-W., Ko, S.-F., Ng, S.-H., Eng, H.-L, Changchien, C.-C. and Huang, C.-C. (2002) Primary osteosarcoma of the uterus with peritoneal osteosarcomatosis. British Journal of Radiology, 75, 772-774.
[5] Sheppard, D.G. and Libshitz, H.I. (2001) Post-radiation Sarcomas: A review of the clinical and imaging features in 63 cases. Clinical Radiology, 56, 22-29. doi:10.1053/crad.2000.0599
[6] Kuttesch Jr., J.F., Wexler, L.H., Marcus, R.B., Fairclough, D., Weaver-McClure, L., White, M., Mao, L., Delaney, T.F., Pratt, C.B., Horowitz, M.E. and Kun, L.E. (1996) Second malignancies after Ewing’s sarcoma: Radiation dose-dependency of secondary sarcomas. Journal of Clinical Oncology, 14, 2818-2825.
[7] Koshy, M., Paulino, A.C., Mai, W.Y. and Teh, B.S. (2005) Radiation-induced osteosarcoma in the pediatric population. International Journal of Radiation Oncology & Biology & Physics, 63, 1169-1174. doi:10.1016/j.ijrobp.2005.04.008
[8] Laskar, S., Mallick, I., Gupta, T. and Muckaden, M.A. (2008) Post-operative radiotherapy for Ewing sarcoma: When, how and how much? Pediatric Blood & Cancer, 51, 575-580. doi:10.1002/pbc.21657
[9] Giuliano, A.E., Feig, S. and Eilber, F.R. (1984) Changing metastatic patterns of osteosarcoma. Cancer, 54, 2160-2164. doi:10.1002/1097-0142(19841115)54:10<2160::AID-CNCR2820541016>3.0.CO;2-P
[10] Heinle, A., Carrasquillo, J.A. and Neumann, R.D. (1989) Two unusual cases of metastatic osteosarcoma detected by Tc-99m MDP bone scintigraphy. Clinical Nuclear Medicine, 14, 889-893. doi:10.1097/00003072-198912000-00006
[11] Westra, A., Schrijvers, D., Somville, J., Van Schil, P., Hubens, G. and Van Oosterom, A. (1998) Late peritoneal metastasis in a patient with osteosarcoma. Annals of Oncology, 9, 907-911. doi:10.1023/A:1008260216130
[12] Rossi, C.R., Casali, P., Kusamura, S., Baratti, D. and Deraco, M. (2008) The consensus statement on the locoregional treatmentof abdominal sarcomatosis. Journal of Surgical Oncology, 98, 291-294.

  
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