TITLE:
Dialogue between estrogen receptor and E2F signaling pathways: The transcriptional coregulator RIP140 at the crossroads
AUTHORS:
Marion Lapierre, Aurélie Docquier, Audrey Castet-Nicolas, Stéphan Jalaguier, Catherine Teyssier, Patrick Augereau, Vincent Cavaillès
KEYWORDS:
RIP140; E2F Transcription Factors; Estrogen Receptors; Gene Expression; Cell Proliferation; Breast Cancer; Endocrine Therapies
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.4 No.10B,
October
8,
2013
ABSTRACT:
Estrogen receptors and E2F transcription factors are the key players of two
nuclear signaling pathways which exert a major role in oncogenesis,
particularly in the mammary gland. Different levels of dialogue between these
two pathways have been deciphered and deregulation of the E2F pathway has been shown to impact the
response of breast cancer cells to endocrine therapies. The present review
focuses on the transcriptional coregulator RIP140/NRIP1 which is involved in
several regulatory feed-back loops and inhibitory cross-talks between different
nuclear signaling pathways. RIP140 regulates the transactivation potential
of estrogen receptors and E2Fs and is also a direct transcriptional target of
these transcription factors. Published data highlight the complex regulation
of RIP140 expression at the transcriptional level and its potential role in
transcription cross-talks. Indeed, a subtle regulation of RIP140 expression levels has important consequences on other transcription networks targeted by
this coregulator. Another level of regulation implies titration mechanisms by
which activation of a pathway leads to sequestration of the RIP140 protein and
thus impinges other gene regulatory circuitries. Altogether, RIP140 occupies a
place of choice in the dialogue between nuclear receptors and E2Fs, which
could be highly relevant in various human pathologies such as cancer or metabolic diseases.