TITLE:
Polymorphisms at GSTM 1, GSTP 1, GSTT 1 Detoxification Genes Loci and Risk of Breast Cancer in Kazakhstan Population
AUTHORS:
T. S. Balmukhanov, A. K. Khanseitova, V. G. Nigmatova, E. E. Ashirbekov, Sh. Zh. Talaeva, N. A. Aitkhozhina
KEYWORDS:
Breast Cancer; Gene Polymorphism; GSTM 1, GSTP 1, GSTT 1 Genes; Kazakhstan
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.2 No.4,
September
9,
2013
ABSTRACT:
Associations of null polymorphism (copy number
variation) of detoxification genes GSTM1, GSTT1 and GSTP1 (at rs2495636, 105 Ile/Val) with the breast cancer (BC) were
assessed in two main ethnic groups of the Republic of Kazakhstan (Kazakhs and
Russians). Total number of patients was 181, and of controls 397. Statistically
significant difference was observed between BC patients and healthy individuals
in alleles frequency (χ2 = 4.89, р = 0.007)
of GSTP1 gene at rs2495636 (105 Ile/Val) among the Kazakhs ethnic group.
Difference in genotypes distribution (χ2 =5.26, р = 0.076) at this site is approximating to be statistically
significant. In the Russian group, no differences were found in
genotypes and alleles atrs 2495636 of GSTP1
gene between cases and controls. There was no significant difference between
null polymorphism (copy number variation) of GSTM1 and GSTT1 genes
among cases and controls in both ethnic groups.