TITLE:
Improved Hemolytic Performance of Blood Pump with Fluorine-Doped Hydrogenated Amorphous Carbon Coating
AUTHORS:
Yasuharu Ohgoe, Masanori Hiratsuka, Hirohito Sumikura, Kazuyoshi Fukunaga, Akihiko Homma, Kenji K. Hirakuri, Akio Funakubo, Yasuhiro Fukui
KEYWORDS:
Fluorine-Doped a-C:H Film; Hemolytic Performance; Artificial Heart Blood Pump
JOURNAL NAME:
Advances in Chemical Engineering and Science,
Vol.3 No.3A3,
August
23,
2013
ABSTRACT:
Fluorine-doped hydrogenated amorphous
carbon (a-C:H:F) film was deposited on a flow-straightener, impeller and diffuser
surface (SUS 304) of an enclosed-impeller type flow blood pump using the
ionization deposition method with a source gas of C6F5H.
The surface characteristics of the a-C:H:F film were examined using atomic
force microscopy, X-ray photoelectron spectroscopy, and measurements of surface
roughness, friction and surface potential. The a-C:H:F film tends to increase
surface roughness and the negative surface charge. In addition, the surface
energy and friction decrease with fluorine dopant in the a-C:H film. To
estimate the hemolytic performance of a blood pump with the a-C:H:F film
coating, the amount of hemolysis was measured using a mock circulatory system (in vitro test) with 500 mL of pig blood
containing sodium citrate. In vitro test was conducted for 180 min with the blood flow and pump head maintained at
5 L/min and 100 mmHg, respectively. The a-C:H:F film coating reduced the amount
of hemolysis and improved the hemolytic performance. Decreasing the surface
energy and negative surface charge of the a-C:H:F film contributes to the
improvement of the hemolytic performance. The a-C:H:F film coating is thus
expected to be utilized in medical technology as a surface coating technology
for artificial heart blood pumps.